Menopausal vasomotor symptoms and adiponectin among midlife women.
Menopausal vasomotor symptoms and adiponectin among midlife women.
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中年女性的更年期血管舒缩症状和脂联素。
DOI：
10.1097/gme.0000000000002039
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Chang,Yuefang
中科院分区：
文献类型：
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作者：
Thurston,RebeccaC;Chang,Yuefang
目的血管运动症状(VMS)是影响生活质量的常见症状。VMS也与心血管疾病风险有关，但这些联系背后的机制尚未阐明。一些最初的工作将VMS与不利的脂肪因子谱或脂肪组织产生的细胞因子联系起来。然而，结果并不完全一致，完全基于自我报告的VMS，这受到一系列记忆和报告偏差的影响。这项工作的目的是测试生理学评估的VMS是否与较低的脂联素相关，脂联素是体内最丰富的脂肪因子，控制混杂因素。我们还考虑了脂联素是否解释了先前文献记载的VMS和颈动脉粥样硬化之间的关系。方法在MsHeart研究中登记的300名围绝经期和绝经后非吸烟女性，年龄在40到60岁之间，包括分析样本。女性没有接受激素治疗或其他影响VMS、胰岛素依赖型糖尿病和心血管疾病的药物。受试者接受动态生理性VMS监测、体格检查、颈动脉超声和空腹静脉抽血。结果更频繁的生理学评估VMS与较低的脂联素(B[SE]=−0.081[0.028]，P=0.004；或在24小时内每增加一个VMS脂联素降低0.081μg/mL)相关，控制了年龄、种族/民族、教育程度、胰岛素抵抗和腰围。内源性雌二醇并不能解释两者之间的联系。脂联素不能解释VMS和颈动脉粥样硬化之间的关联。结论考虑潜在的混杂因素后，生理性VMS与较低的脂联素有关。脂肪因子在VMS中以及在VMS与健康之间的联系中的作用值得进一步关注。
ObjectiveVasomotor symptoms (VMS) are prevalent symptoms that can have a negative impact on quality of life. VMS have also been linked to cardiovascular disease risk, yet the mechanisms underlying these associations have not been elucidated. Some initial works link VMS to adverse adipokine profiles or cytokines produced by adipose tissue. However, results are not entirely consistent and are based entirely on self-report VMS, which is influenced by a range of memory and reporting biases. The aim of this work was to test whether physiologically assessed VMS are associated with lower adiponectin, the most abundant adipokine in the body, controlling for confounding factors. We also consider whether adiponectin explains previously documented relationships between VMS and carotid atherosclerosis.MethodsA total of 300 peri-and postmenopausal nonsmoking women aged 40 to 60 years enrolled in the MsHeart study comprised the analytic sample. Women were free of hormone therapy or other medications impacting VMS, insulin-dependent diabetes, and cardiovascular disease. Participants underwent ambulatory physiologic VMS monitoring, physical measures, a carotid ultrasound, and fasting phlebotomy.ResultsMore frequent physiologically assessed VMS were associated with lower adiponectin (B [SE]=− 0.081 [0.028], P= 0.004; or 0.081 lower μg/mL in adiponectin for each additional VMS over 24 hours), controlling for age, race/ethnicity, education, insulin resistance, and waist circumference. Associations were not explained by endogenous estradiol. Adiponectin did not explain associations between VMS and carotid atherosclerosis.ConclusionsPhysiologic VMS were associated with lower adiponectin after considering potential confounders. The role of adipokines in VMS and in links between VMS and health warrants further attention.