Kallistatin inhibits tumour progression and platinum resistance in high-grade serous ovarian cancer
Kallistatin inhibits tumour progression and platinum resistance in high-grade serous ovarian cancer
复制标题
卡利他汀抑制高级别浆液性卵巢癌的肿瘤进展和铂耐药
DOI：
10.1186/s13048-019-0601-6
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发表时间：
2019-12
期刊：
影响因子：
--
通讯作者：
Beihua Kong
中科院分区：
文献类型：
--
作者：
Huan Wu;Rongrong Li;Zhiwei Zhang;Huiyang Jiang;Hanlin Ma;Cunzhong Yuan;Chenggong Sun;Yingwei Li;Beihua Kong
卵巢癌是最致命的妇科恶性肿瘤。虽然卵巢癌有各种亚型，但高级别浆液性卵巢癌（HGSOC）占卵巢癌死亡的70%。化疗耐药是HGSOC预后不良的主要原因。激肽释放酶抑制剂（KAL），也称为丝氨酸蛋白酶抑制剂4，是丝氨酸蛋白酶抑制剂家族的一部分。已经发现激肽抑制素对血管生成、炎症和肿瘤进展发挥多种作用。然而，Kallistatin在HGSOC中的作用和临床意义尚不清楚。在这里，我们表明，激肽在HGSOC显着下调相比，正常输卵管（FT）组织。Kallistatin的低表达与HGSOC的不良预后和铂类耐药相关。Kallistatin过表达可显著抑制卵巢癌细胞的增殖和转移，增强铂敏感性和凋亡。总的来说，这些研究结果表明，激肽释放酶抑制剂作为一个预后预测因子，并提供了一个潜在的治疗靶点HGSOC。
Ovarian cancer is the most lethal gynaecologic malignancy. Although there are various subtypes of ovarian cancer, high-grade serous ovarian cancer (HGSOC) accounts for 70% of ovarian cancer deaths. Chemoresistance is the primary reason for the unfavourable prognosis of HGSOC. Kallistatin (KAL), also known as SERPINA4, is part of the serpin family. Kallistatin has been discovered to exert multiple effects on angiogenesis, inflammation and tumour progression. However, the roles and clinical significance of kallistatin in HGSOC remain unclear. Here, we showed that kallistatin was significantly downregulated in HGSOC compared to normal fallopian tube (FT) tissues. Low expression of kallistatin was associated with unfavourable prognosis and platinum resistance in HGSOC. Overexpression of kallistatin significantly inhibited proliferation and metastasis, and enhanced platinum sensitivity and apoptosis in ovarian cancer cells. Collectively, these findings demonstrate that kallistatin serves as a prognostic predictor and provide a potential therapeutic target for HGSOC.
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DOI：
10.1891/9780826121646.0002
发表时间：
2018-09
期刊：
Cancer Rehabilitation
影响因子：
--
作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
通讯作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
卡利他汀通过下调VEGF-C表达和分泌抑制胃癌淋巴管生成和淋巴转移
影响因子：
7.4
作者：
Ma, Caiqi;Luo, Chuanghua;Yang, Xia
通讯作者：
Yang, Xia
影响因子：
5.5
作者：
Miao, RQ;Chen, V;Chao, J
通讯作者：
Chao, J
影响因子：
5.3
作者：
通讯作者：
--
影响因子：
5.7
作者：
B. Zhu;Lei Lu;Weibin Cai;Xia Yang;Chaoyang Li;Zhonghan Yang;Wenhua Zhan;Jian-xing Ma;G. Gao
通讯作者：
B. Zhu;Lei Lu;Weibin Cai;Xia Yang;Chaoyang Li;Zhonghan Yang;Wenhua Zhan;Jian-xing Ma;G. Gao