Isolation of a spiral-shaped bacterium from the cat stomach
Isolation of a spiral-shaped bacterium from the cat stomach
复制标题
从猫胃中分离螺旋形细菌
作者：
Adrian Lee;S. Hazell;J. O'Rourke;S. Kouprach
首次在纯培养物中分离出一种寄生在猫胃中的螺旋形细菌。该生物体紧密盘绕，在细胞末端有10至17根极鞭毛，位置稍微偏离中心。细胞体被独特的周质原纤维包围，这些原纤维通常成对出现，尽管也可以看到一个和三个原纤维的组合。该微生物是强烈的尿素酶，过氧化氢酶和氧化酶阳性，很可能属于一个尚未分类的细菌群，特别是适应胃肠道粘液提供的生态位。分离该微生物将允许研究影响胃粘膜定植的因素，与另一种粘液定植者幽门弯曲杆菌与人类胃的关联相关的信息。最近有报道分离出了具有特征性周质表面结构的其他细菌，这表明该菌群可能比迄今为止所认为的更为广泛。在人类胃活组织检查中发现了与猫胃中所见生物体形态相同的细菌。本文报道的分离的微生物已在以前的血清学研究中使用，以支持动物螺旋菌可以在人类胃中定植的假设。
A spiral- or helix-shaped bacterium that colonizes the stomachs of cats has been isolated in pure culture for the first time. The organism is tightly coiled with tufts of 10 to 17 polar flagella positioned slightly off center at the end of the cell. The body of the cell is entwined with unique periplasmic fibrils that usually occur in pairs, although groupings of one and three fibrils were also seen. The organism is strongly urease, catalase, and oxidase positive and is likely to belong to an as yet unclassified group of bacteria that are specifically adapted to the ecological niche provided by gastrointestinal mucus. Isolation of this organism will allow study of the factors influencing colonization of gastric mucosae, information relevant to the association of another mucus colonizer, Campylobacter pylori, with the human stomach. Recent reports of the isolation of other bacteria with the characteristic periplasmic surface structures suggests that the group may be more widespread than was hitherto thought. Bacteria with the morphology of the organisms seen in the cat stomach have been seen in gastric biopsies from humans. The organism whose isolation is reported here has been used in previous serological studies to support the hypothesis that spiral bacteria from animals can colonize the human stomach.