18F-Fluoride PET/CT for detection of sacroiliitis in ankylosing spondylitis
18F-Fluoride PET/CT for detection of sacroiliitis in ankylosing spondylitis
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DOI：
10.1007/s00259-010-1464-7
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发表时间：
2010-08-01
影响因子：
9.1
通讯作者：
Ciurea, Adrian
中科院分区：
文献类型：
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作者：
Strobel, Klaus;Fischer, Dorothee R.;Ciurea, Adrian
为评价F-18-氟化物-PET/CT(PET/CT)对活动期强直性脊柱炎(AS)患者的诊断价值。对15例AS患者(AS组)和13例机械性下腰痛(MLBP；对照组)患者进行了全身F-18-氟化物PET/CT检查。30个AS组量化关节的SIJ/S比值平均为1.66(1.10~3.07)，MLBP组26个量化关节的SIJ/S比值平均为1.12(0.71~1.52)。SIJ关节炎受试者工作特征曲线下面积为0.84。以X线平片为金标准，以SIJ/S比值>；1.3为临界值，每例患者的敏感性、特异性和准确性分别为80%、77%和79%。在SIJ基础上，3级(n=16)的灵敏度最高(94%)。我们的结果提示，定量的F-18-氟化物PET/CT可以在活动期强直性脊柱炎的诊断中发挥作用，在钼缺乏的时候可以替代传统的骨显像。
The aim of this study was to evaluate the performance of F-18-fluoride-PET/CT (PET/CT) for the diagnosis of sacroiliac joint (SIJ) arthritis in patients with active ankylosing spondylitis (AS).Included in the study were 15 patients with AS according to the modified New York criteria (AS group) and with active disease and 13 patients with mechanical low back pain (MLBP; control group) who were investigated with whole-body F-18-fluoride PET/CT. The ratio of the uptake in the SIJ and that in the sacrum (SIJ/S) was calculated for every joint.The mean SIJ/S ratio of 30 quantified joints in the AS group was 1.66 (range 1.10-3.07) with PET/CT, and the mean SIJ/S ratio of 26 quantified joints in the MLBP group was 1.12 (range 0.71-1.52). The area under the receiver operating characteristic curve for SIJ arthritis was 0.84. With plain radiography as a the gold standard and taking an SIJ/S ratio of > 1.3 as the threshold, the sensitivity, specificity and accuracy on a per patient basis were 80%, 77% and 79%, respectively. On a per SIJ basis, the greatest sensitivity (94%) was found in grade 3 sacroiliitis (n = 16).Our results suggest that quantitative F-18-fluoride PET/CT may play a role in the diagnosis of sacroiliitis in active AS and is an alternative to conventional bone scintigraphy in times of molybdenum shortage.