Daytime sleep condenses the time course of motor memory consolidation
Daytime sleep condenses the time course of motor memory consolidation
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DOI：
10.1038/nn1959
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发表时间：
2007-09-01
影响因子：
25
通讯作者：
Karni, Avi
中科院分区：
文献类型：
--
作者：
Korman, Maria;Doyon, Julien;Karni, Avi
两种行为现象表征了人类运动记忆巩固：减少对后续经验干扰的敏感性，以及出现延迟的离线性能增益。最近的一个模型提出，睡眠独立的干扰减少之后，由睡眠依赖的离线增益的表达。在这里，使用的手指反对序列学习任务，我们表明，在2小时，但不是8小时，经历了干扰，在初始训练后，防止在24小时后的延迟增益的表达培训。然而，一个90分钟的午睡，立即培训后，显着降低了对干扰的敏感性，与强大的延迟收益表示过夜，尽管在2小时后的干扰培训。在没有干扰的情况下，午睡导致延迟增益在训练后8小时内更早表达。这些结果表明，干扰的鲁棒性的演变和延迟增益的演变可以立即在训练后一致，这两种效果反映了睡眠敏感的过程。
Two behavioral phenomena characterize human motor memory consolidation: diminishing susceptibility to interference by a subsequent experience and the emergence of delayed, offline gains in performance. A recent model proposes that the sleep-independent reduction in interference is followed by the sleep-dependent expression of offline gains. Here, using the finger-opposition sequence-learning task, we show that an interference experienced at 2 h, but not 8 h, following the initial training prevented the expression of delayed gains at 24 h post-training. However, a 90-min nap, immediately post-training, markedly reduced the susceptibility to interference, with robust delayed gains expressed overnight, despite interference at 2 h post-training. With no interference, a nap resulted in much earlier expression of delayed gains, within 8 h post-training. These results suggest that the evolution of robustness to interference and the evolution of delayed gains can coincide immediately post-training and that both effects reflect sleep-sensitive processes.