NanoVelcro-captured CTC number concomitant with enhanced serum levels of MMP7 and MMP9 enables accurate prediction of metastasis and poor prognosis in patients with lung adenocarcinoma.
NanoVelcro-captured CTC number concomitant with enhanced serum levels of MMP7 and MMP9 enables accurate prediction of metastasis and poor prognosis in patients with lung adenocarcinoma.
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NanoVelcro 捕获的 CTC 数量伴随着 MMP7 和 MMP9 血清水平的增强，能够准确预测肺腺癌患者的转移和不良预后
DOI：
10.2147/ijn.s144033
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发表时间：
2017
影响因子：
8
通讯作者：
Ke Z
中科院分区：
文献类型：
--
作者：
Sun Y;Chen Y;Li S;Lei Y;Xu D;Jiang N;Zhang Y;Cao J;Ke Z
肺腺癌（LADC）是最恶性的癌症之一，即使在疾病的早期阶段也经常发生微转移。循环肿瘤细胞（CTC）数量、基质金属蛋白酶（MMP）7和MMP 9在许多肿瘤中显示出作为预测生物标志物的巨大前景。然而，这些生物标志物之间的相互作用及其在LADC转移和预后中作用的分子基础仍不清楚。目前的研究表明，CTC计数升高和MMP 7和MMP 9的过表达与LADC患者（n=143）的转移和临床进展相关。此外，MMP 7和MMP 9上调促进体外LADC细胞迁移并提高异种移植小鼠模型中的血清CTC水平。更重要的是，受试者工作特征（ROC）曲线和Kaplan-Meier分析证实了CTC、MMP 7和MMP 9组合组对转移和总生存期（OS）的预测更准确。综上所述，我们的数据首次显示了MMP 7和MMP 9参与CTCs释放到外周血中，并且我们的数据揭示了CTC计数和MMP 7和MMP 9的表达可以一起用作LADC转移和预后的有效临床预测面板。
Lung adenocarcinoma (LADC) is among the most malignant cancers that frequently develops micrometastases even in early stages of the disease. Circulating tumor cell (CTC) number, matrix metalloproteinase (MMP) 7, and MMP9 show great prospects as predictive biomarkers in many tumors. However, the interactions between these biomarkers and the molecular basis of their roles in the metastasis and prognosis of LADC remain unclear. The present study revealed that an elevated CTC count and overexpression of MMP7 and MMP9 correlate with metastasis and clinical progression in LADC patients (n=143). Furthermore, MMP7 and MMP9 upregulation facilitates LADC cell migration in vitro and enhances serum CTC levels in a xenograft mouse model. More importantly, receiver operating characteristic (ROC) curves and Kaplan–Meier analysis confirmed more accurate prediction of metastasis and overall survival (OS) with a combination panel of CTC, MMP7, and MMP9. Taken together, our data show, for the first time, the involvement of MMP7 and MMP9 in the release of CTCs into the peripheral blood, and our data reveal that CTC count and expression of MMP7 and MMP9 can be used together as an effective clinical prediction panel for LADC metastasis and prognosis.