Transcranial direct current stimulation improves naming reaction time in fluent aphasia: a double-blind, sham-controlled study.
Transcranial direct current stimulation improves naming reaction time in fluent aphasia: a double-blind, sham-controlled study.
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DOI：
10.1161/strokeaha.110.600288
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发表时间：
2011-03
期刊：
影响因子：
8.3
通讯作者：
Rorden C
中科院分区：
文献类型：
--
作者：
Fridriksson J;Richardson JD;Baker JM;Rorden C
先前的证据表明，应用于左半球的阳极经颅直流电刺激（A-tDCS）可以提高失语症参与者命名常见物体的能力。目前的研究在一个更严格控制的实验中进一步研究了这个问题，实验对象是流利性失语症患者。我们研究了八名慢性中风参与者在公开图片命名过程中A-tDCS对反应时间（RT）的影响。阳极电极放置靶向病变周围脑区，这些脑区在明显图片命名期间进行的治疗前fMRI扫描中显示出最大的激活，参考阴极电极放置在对侧前额上。在交叉设计中，将A-tDCS（1 mA; 20 min）与假tDCS（S-tDCS）进行比较。参与者接受了十次计算机化失范治疗;五次包括A-tDCS，五次包括S-tDCS。将A-tDCS与行为语言治疗相结合，在治疗后立即命名训练项目时减少了RT，Z=1.96，p=.025，在三周后的后续测试中，Z=2.52，p=.006。在语言治疗过程中，A-tDCS减少了流利的失语症参与者在图片命名过程中的处理时间。建议将A-tDCS（一种没有严重副作用的廉价方法）与行为语言疗法相结合的其他研究。
Previous evidence suggests that anodal transcranial direct current stimulation (A-tDCS) applied to the left hemisphere can improve aphasic participants’ ability to name common objects. The current study further examined this issue in a more tightly controlled experiment in participants with fluent aphasia. We examined the effect of A-tDCS on reaction time (RT) during overt picture naming in eight chronic stroke participants. Anode electrode placement targeted peri-lesional brain regions that showed the greatest activation on a pre-treatment fMRI scan administered during overt picture naming, with the reference cathode electrode placed on the contralateral forehead. A-tDCS (1 mA; 20-min) was compared to sham tDCS (S-tDCS) in a cross-over design. Participants received ten sessions of computerized anomia treatment; five sessions included A-tDCS and five included S-tDCS. Coupling A-tDCS with behavioral language treatment reduced RT during naming of trained items immediately post-treatment, Z=1.96, p=.025, and at subsequent testing three weeks later, Z=2.52, p=.006. A-tDCS administered during language treatment decreased processing time during picture naming by fluent aphasic participants. Additional studies combining A-tDCS, an inexpensive method with no reported serious side effects, with behavioral language therapy are recommended.