A new approach to analysis of the arterial baroreflex.
A new approach to analysis of the arterial baroreflex.
复制标题
分析动脉压力反射的新方法。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
G. Mancia
中科院分区：
文献类型：
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作者：
G. Bertinieri;M. Rienzo;Anita Cavallazzi;A. Ferrari;A. Pedotti;G. Mancia
动脉压力反射通常是通过测量脉搏间隔的延长和缩短来评估的，这是对输注血管加压药和血管降压药引起的收缩压(S)变化的反应。该方法简单，但有重要的局限性：只能进行少量观察，反应的可重复性远未达到最佳，不能排除直接药物作用于窦结和压力感受器的干扰，人工诱导的刺激只能很好地模拟自然发生的升压和降压瞬变。因此采取了一种新的办法。在10只未麻醉、不受约束的猫的动脉内记录3 +/- 0.4 h（平均+/- s.d）的血压，并通过计算机扫描记录，以识别三次或三次以上连续搏动的自发序列，其中收缩压逐渐升高、脉间隔逐渐延长（1型序列）或收缩压逐渐下降、脉间隔逐渐缩短（2型序列）。采用非常窄的BP迹线采样间隔，即实时1.6 ms，获得了精确的收缩压和脉冲间隔的拍对拍测量。对于每个序列，计算收缩压值与下一个周期脉冲内部值之间的回归。在每只猫身上都发现了大量的三拍序列，然而，四拍、五拍和六拍序列逐渐减少。所有序列均有较高的相关系数（r > 0.9）， 1型比2型斜率更大（14.1 +/- 2.5 vs 10.3 +/- 7.6 ms/mmHg, P < 0.01）。（摘要删节250字）
The arterial baroreflex is commonly evaluated by measuring the lengthening and shortening in pulse interval in response to changes in systolic (S) blood pressure (BP) induced by infusion of vasopressor and vasodepressor drugs. This method is simple but has important limitations: only a few observations can be made, reproducibility of the responses is far from optimal, interference by direct drug action on the sinus node and the baroreceptors cannot be excluded and the artificially induced stimuli only poorly mimic the naturally occurring pressor and depressor transients. A new approach was therefore pursued. Blood pressure was recorded intra-arterially for 3 +/- 0.4 h (mean +/- s.d) in 10 unanaesthetized, unrestrained cats and the recording was scanned by a computer to identify the spontaneous sequences of three or more consecutive beats in which SBP progressively rose and pulse interval progressively lengthened (type 1 sequence) or SBP progressively fell and pulse interval progressively shortened (type 2 sequences). Accurate beat-to-beat measurements of SBP and pulse interval were obtained by adopting a very narrow sampling interval of the BP trace, i.e. 1.6 ms real time. For each sequence the regression between the SBP values and the pulse internal values of the following cycle was calculated. In each cat a large number of three-beat sequences were found, the four-, five- and six-beat sequences being, however, progressively less common. All sequences had a high correlation coefficient (r > 0.9), type 1 having a greater slope than type 2 (14.1 +/- 2.5 versus 10.3 +/- 7.6 ms/mmHg, P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)