Metabolic and genetic risk factors for migraine in children
Metabolic and genetic risk factors for migraine in children
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DOI：
10.1111/j.1468-2982.2006.01107.x
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发表时间：
2006-06-01
期刊：
影响因子：
4.9
通讯作者：
Molinari, AC
中科院分区：
文献类型：
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作者：
Bottini, F;Celle, ME;Molinari, AC
偏头痛可诱发缺血性脑卒中，被认为是年轻人脑卒中的独立危险因素。迄今为止，偏头痛和中风之间的联系本质上是未知的。研究了45名儿童。检测同型半胱氨酸水平（空腹和蛋氨酸负荷后）、维生素B12和血浆叶酸水平、因子V Leiden、因子II G20210 A、亚甲基四氢叶酸还原酶（MTHFR）C677 T和A1298 C突变。与对照组相比，偏头痛患者蛋氨酸负荷后同型半胱氨酸水平较高（19.5 +/- 4.9 vs. 16.9 +/- 1.9; P = 0.025），叶酸水平显著较低（5.8 +/- 2.6 vs. 7.5 +/- 2.1; P = 0.002）。我们发现，在携带MTHFR C677 T和MTHFR A1298 C多态性纯合突变基因型的受试者中，偏头痛的风险有增加的趋势。遗传性血栓前状态似乎与年轻人的偏头痛无关，而偏头痛患者和对照组之间的生化差异是一个值得进一步研究的有吸引力的话题。
Migraine can induce ischaemic stroke, and is considered an independent risk factor for stroke in the young. To date, the nature of the link between migraine and stroke is essentially unknown. Forty-five children were studied. Homocysteine levels (fasting and post methionine load), vitamin B12 and plasma folate levels, factor V Leiden, factor II G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C mutations were examined. Compared with controls, patients with migraine had higher levels of post-methionine load homocysteine values (19.5 +/- 4.9 vs. 16.9 +/- 1.9; P = 0.025) and significantly lower folate levels (5.8 +/- 2.6 vs. 7.5 +/- 2.1; P = 0.002). We found a trend toward an increased risk of migraine in subjects carrying a homozygous mutant genotype for MTHFR C677T and MTHFR A1298C polymorphisms. Genetic prothrombotic conditions do not seem to be related to migraine in the young, whereas the biochemical differences between migrainous patients and controls are an appealing topic for further investigation.