Representation of UV-B-induced Thermal and Mechanical Hyperalgesia in the Human Brain: A Functional MRI Study
Representation of UV-B-induced Thermal and Mechanical Hyperalgesia in the Human Brain: A Functional MRI Study
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DOI：
10.1002/hbm.20470
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发表时间：
2008-12-01
影响因子：
4.8
通讯作者：
Maihoefner, Christian
中科院分区：
文献类型：
--
作者：
Seifert, Frank;Jungfer, Isabella;Maihoefner, Christian
疼痛和痛觉过敏的替代模型允许在健康志愿者中调查潜在的机制。在这里，我们研究了大脑激活模式在机械和热痛觉过敏的炎症人类疼痛模型，使用功能性磁共振成像。在14名健康受试者的右前臂上应用UV-B诱导热和机械痛觉过敏。所有四种情况（非致敏热和非致敏机械性疼痛，致敏热和致敏机械性疼痛）的感知匹配。进行2 × 2因子分析。主要致敏效应区域为丘脑、前扣带皮层（ACC）、前额叶皮层（PFC）、顶叶联合皮层（PA）、丘脑和基底节。热痛觉过敏时激活较多的通道主要作用于初级躯体感觉皮层（S1）、ACC、PFC和PA。在机械痛觉过敏过程中，激活更多的方式的主要影响被发现在次级躯体感觉皮层，后额叶皮层，和对侧下额叶皮层（IFC）。在IFC中，发现了敏感性和模式的相互作用。在两种刺激方式中具有相似致敏效应的区域是ACC、双侧前额叶和双侧IFC。我们的结论是，不同类型的痛觉过敏的炎症性疼痛的人类替代模型产生不同的大脑激活模式。这部分是由于热痛和机械痛的差异处理以及IFC尾部的致敏和模态的相互作用。最后，数据提供的证据表明，存在一个共同的“敏感网络”，包括ACC，双边前额叶，和IFC的部分。《编织地图》29：1327-1342，2008年。(C)2007 Wiley-Liss，Inc.
Surrogate models of pain and hyperalgesia allow the investigation of underlying mechanisms in healthy volunteers. Here, we investigated brain activation patterns during mechanical and heat hyperalgesia in an inflammatory human pain model using functional magnetic resonance imaging. Heat and mechanical hyperalgesia were induced on the right forearm by UV-B application in 14 healthy subjects. All four conditions (nonsensitized heat and nonsensitized mechanical pain, sensitized heat and sensitized mechanical pain) were perceptually matched. A 2 X 2 factorial analysis was performed. Areas with main effect of sensitization were insula, anterior cingulate cortex (ACC), prefrontal cortices (PFC), parietal association cortices (PA), thalamus, and basal ganglia. A main effect of modality with more activation during heat hyperalgesia was found in primary somatosensory cortex (S1), ACC, PFC, and PA. A main effect of modality with more activation during mechanical hyperalgesia was found in secondary somatosensory cortices, posterior insula, and contralateral inferior frontal cortex (IFC). An interaction of sensitization and modality was found bilaterally in IFC. Areas with similar effects of sensitization in both stimulus modalities were ACC, bilateral anterior insula and bilateral IFC. We conclude that different types of hyperalgesia in a human surrogate model of inflammatory pain produce different brain activation patterns. This is partly due to a differential processing of thermal and mechanical pain and an interaction of sensitization and modality in the caudal portion of the IFC. Finally, the data provide evidence for the existence of a common "sensitization network" consisting of ACC, bilateral anterior insula, and parts of the IFC. Hum Braid Mapp 29:1327-1342, 2008. (C) 2007 Wiley-Liss, Inc.