QUANTITATIVE ASPECTS OF REPETITIVE FIRING OF MAMMALIAN MOTONEURONES, CAUSED BY INJECTED CURRENTS
QUANTITATIVE ASPECTS OF REPETITIVE FIRING OF MAMMALIAN MOTONEURONES, CAUSED BY INJECTED CURRENTS
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DOI：
10.1113/jphysiol.1963.sp007230
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发表时间：
1963-01-01
影响因子：
5.5
通讯作者：
KERNELL, D
中科院分区：
文献类型：
--
作者：
GRANIT, R;SHORTESS, GK;KERNELL, D
In response to long-lasting trans-membrane depolarization by current through the tip of the micro-electrode a number of rat and cat motoneurones set up a steady discharge during stimulation. The frequency of discharge is linearly related to current strength within a range of physiological frequency variation. The steady state of firing is preceded by a brief phase of "adaptation" during which impulse frequency diminishes at a rate varying from cell to cell and depending on current strength. Early in adaptation, during the delivery of initial spikes, after-hyperpolariza -tion develops and contributes to the adaptive process by diminishing firing rate. A second component of adaptation is a true opposing activity on the part of the membrane leading to an increase of threshold and characterized by a drop in the value of the slope constants of the curves relating firing rate to current strength. In tonic cells the adaptive process is generally over in some tenth of a second. Slope constants are given for the steady state of firing in 10 rat and 6 cat cells. The latter fired at a lower average rate. The discussion deals with the general significance of measurements of slope constants and firing thresholds for the understanding of neural control as well as with some problems of accomodation and adaptation.
