Effect of choline carboxylate ionic liquids on biological membranes.
Effect of choline carboxylate ionic liquids on biological membranes.
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DOI：
10.1016/j.colsurfb.2014.09.057
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发表时间：
2014-11-01
期刊：
影响因子：
--
通讯作者：
Kunz W
中科院分区：
文献类型：
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作者：
Rengstl D;Kraus B;Van Vorst M;Elliott GD;Kunz W
胆碱羧酸盐（ChCm）（m = 2-10）和胆碱油酸盐被认为是生物相容性物质，但它们对生物膜的影响并不为人所知，并且对人类皮肤的影响以前也没有研究过。m = 2，4，6的短链胆碱羧酸酯ChCm在水溶液中起增溶疏水化合物的助水溶物作用，而m = 8，10的长链胆碱羧酸酯ChCm能与油酸酯形成胶束。在本研究中，使用HeLa和SK-MEL-28细胞测试羧酸胆碱的细胞毒性。这些物质对二棕榈酰磷脂酰胆碱（DPPC）制备的脂质体的影响也进行了评价，以提供对膜相互作用的见解。观察到具有m > 8的链长的胆碱羧酸盐明显地影响双层，而较短的胆碱羧酸盐与脂质体的相互作用最小。
Choline carboxylates, ChCm, with m = 2–10 and choline oleate are known as biocompatible substances, yet their influence on biological membranes is not well-known, and the effect on human skin has not previously been investigated. The short chain choline carboxylates ChCm with m = 2, 4, 6 act as hydrotropes, solubilizing hydrophobic compounds in aqueous solution, while the longer chain choline carboxylates ChCm with m = 8,10 and oleate are able to form micelles. In the present study, the cytotoxicity of choline carboxylates was tested using HeLa and SK-MEL-28 cells. The influence of these substances on liposomes prepared from dipalmitoylphosphatidylcholine (DPPC) was also evaluated to provide insights on membrane interactions. It was observed that the choline carboxylates with a chain length of m > 8 distinctly influence the bilayer, while the shorter ones had minimal interaction with the liposomes.