Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study
Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study
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DOI：
10.1093/brain/awl050
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发表时间：
2006-08-01
期刊：
影响因子：
14.5
通讯作者：
Hallett, M.
中科院分区：
文献类型：
--
作者：
Bohlhalter, S.;Goldfine, A.;Hallett, M.
人们对抽动和相关冲动的神经关联知之甚少。在本研究中，我们旨在通过事件相关功能磁共振成像（fMRI）探讨抽动秽语综合征患者抽动的神经基础。对 10 名患者（6 名女性，4 名男性；年龄：平均值 +/- SD = 31 +/- 11.2）进行了研究，同时自发表现出各种运动和发声抽搐。在同步视频/音频记录的基础上，分析抽动发作前 2 秒和抽动发作时的功能磁共振成像活动，无论临床现象如何。我们确定了一个由旁边缘区域组成的大脑网络，例如前扣带皮层和岛叶皮质、辅助运动区 (SMA) 和顶叶盖 (PO) 在抽动发作前主要激活（P < 0.05，针对多重比较进行了校正）。相反，在抽动动作开始时，在感觉运动区域（包括双侧顶上小叶和小脑）发现显着的 fMRI 活动。这项研究的结果表明，旁边缘和感觉关联区域与抽动的产生密切相关，类似于由不愉快的感觉引发的内部运动，如疼痛或瘙痒所示。
Little is known about the neural correlates of tics and associated urges. In the present study, we aimed to explore the neural basis of tics in patients with Tourette syndrome by using event-related functional MRI (fMRI). Ten patients (6 women, 4 men; age: mean +/- SD = 31 +/- 11.2) were studied while spontaneously exhibiting a variety of motor and vocal tics. On the basis of synchronized video/audio recordings, fMRI activities were analysed 2 s before and at tic onset irrespective of the clinical phenomenology. We identified a brain network of paralimbic areas such as anterior cingulate and insular cortex, supplementary motor area (SMA) and parietal operculum (PO) predominantly activated before tic onset (P < 0.05, corrected for multiple comparisons). In contrast, at the beginning of tic action, significant fMRI activities were found in sensorimotor areas including superior parietal lobule bilaterally and cerebellum. The results of this study indicate that paralimbic and sensory association areas are critically implicated in tic generation, similar to movements triggered internally by unpleasant sensations, as has been shown for pain or itching.