British Isles Lupus Assessment Group 2004 index is valid for assessment of disease activity in systemic lupus erythematosus
British Isles Lupus Assessment Group 2004 index is valid for assessment of disease activity in systemic lupus erythematosus
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DOI：
10.1002/art.23130
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发表时间：
2007-12-01
影响因子：
--
通讯作者：
Gordon, Caroline
中科院分区：
文献类型：
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作者：
Yee, Chee-Seng;Farewell, Vernon;Gordon, Caroline
Objective.确定不列颠群岛狼疮评估小组2004年（BILAG-2004）指数的结构和标准效度，以评估系统性红斑狼疮（SLE）的疾病活动性。SLE患者被纳入一项多中心横断面研究。收集SLE疾病活动性（BILAG-2004指数、经典BILAG指数和系统性红斑狼疮疾病活动性指数2000 [SLEDAI-2K]评分）、检查和治疗的数据。总体BILAG-2004和总体经典BILAG评分由任何单个系统在相应指数中获得的最高评分确定。红细胞沉降率（ESR），C3水平，C4水平，抗双链DNA（anti-dsDNA）水平和SLEDAI-2K评分用于结构效度分析，并在标准效度分析中使用治疗的增加作为活动性疾病的标准。统计分析采用有序逻辑回归分析结构效度和逻辑回归分析标准效度。计算敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）。在369例SLE患者中，92.7%为女性，59.9%为白色，18.4%为非洲裔加勒比人，18.4%为南亚人。他们的平均± SD年龄为41.6 ± 13.2岁，平均病程为8.8 ± 7.7年。88.6%的患者获得了I以上的评估，共获得了1，510次评估。BILAG-2004指数总分增加与ESRs增加、C3水平降低、C4水平降低、抗ds-DNA水平升高和SLEDAI-2K评分增加相关（均P < 0.01）。在总体BILAG-2004评分反映疾病活动性较高的患者中，更频繁地观察到治疗增加。提示活动性疾病的评分（BILAG-2004总体评分为A和B）与治疗增加显著相关（比值比[OR] 19.3，P < 0.01）。BILAG-2004和经典BILAG指数的敏感性、特异性、PPV和NPV相当。这些结果表明，BILAG-2004指数具有结构效度和效标效度。
Objective. To determine the construct and criterion validity of the British Isles Lupus Assessment Group 2004 (BILAG-2004) index for assessing disease activity in systemic lupus erythematosus (SLE).Methods. Patients with SLE were recruited into a multicenter cross-sectional study. Data on SLE disease activity (scores on the BILAG-2004 index, Classic BILAG index, and Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI-2K]), investigations, and therapy were collected. Overall BILAG-2004 and overall Classic BILAG scores were determined by the highest score achieved in any of the individual systems in the respective index. Erythrocyte sedimentation rates (ESRs), C3 levels, C4 levels, anti-double-stranded DNA (anti-dsDNA) levels, and SLEDAI-2K scores were used in the analysis of construct validity, and increase in therapy was used as the criterion for active disease in the analysis of criterion validity. Statistical analyses were performed using ordinal logistic regression for construct validity and logistic regression for criterion validity. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated.Results. Of the 369 patients with SLE, 92.7% were women, 59.9% were white, 18.4% were Afro-Caribbean and 18.4% were South Asian. Their mean +/- SD age was 41.6 +/- 13.2 years and mean disease duration was 8.8 +/- 7.7 years. More than I assessment was obtained on 88.6% of the patients, and a total of 1,510 assessments were obtained. Increasing overall scores on the BILAG-2004 index were associated with increasing ESRs, decreasing C3 levels, decreasing C4 levels, elevated antids-DNA levels, and increasing SLEDAI-2K scores (all P < 0.01). Increase in therapy was observed more frequently in patients with overall BILAG-2004 scores reflecting higher disease activity. Scores indicating active disease (overall BILAG-2004 scores of A and B) were significantly associated with increase in therapy (odds ratio [OR] 19.3, P < 0.01). The BILAG-2004 and Classic BILAG indices had comparable sensitivity, specificity, PPV, and NPV.Conclusion. These findings show that the BILAG-2004 index has construct and criterion validity.