Bioactive compounds from the fern Lepisorus contortus.
Bioactive compounds from the fern Lepisorus contortus.
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来自蕨类植物 Lepisorus contortus 的生物活性化合物。
DOI：
10.1021/np100373f
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发表时间：
2011
影响因子：
5.1
通讯作者：
中科院分区：
文献类型：
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作者：
Yang,Jian-Hong;Kondratyuk,TamaraP;Jermihov,KatherineC;Marler,LauraE;Qiu,Xi;Choi,Yongsoo;Cao,Hongmei;Yu,Rui;Sturdy,Megan;Huang,Rong;Liu,Ying;Wang,Li-Qin;Mesecar,AndrewD;vanBreemen,RichardB;Pezzuto,JohnM;Fong,HarryHS;
通过对扭叶瓦韦全株的植物化学研究，分离出了5个新的苯乙醇苷（1−5），每个都含有一个咖啡酰基，一个新的黄酮苷（10）和14个已知化合物（6− 9和11 −15，胡萝卜酸，香草酸，根皮酸，diplopterol和β-谷甾醇）。这是水龙骨科中苯乙醇苷类化合物的首次报道。基于化合物1 - 15抑制肿瘤坏死因子α（TNF-α）诱导的NF-κB活性、一氧化氮（NO）产生以及芳香酶、醌还原酶2（QR-2）和考克斯-1/-2活性的能力，评价了化合物1 - 15的癌症化学预防潜力。槲皮素-3-O-β-d-葡萄糖苷（15）对QR 2表现出抑制作用，IC 50值为3.84 μM，这证实山奈酚/槲皮素糖苷是抑制QR 2的活性化合物。该化合物还表现出NF-κB活性，IC 50值为33.6 μM。此外，化合物1、2、4和6显示芳香化酶活性，IC 50值分别为30.7、32.3、26.8和35.3 μM。
Phytochemical investigation of the whole plant ofLepisorus contortus(Christ) Ching led to the isolation of five new phenylethanoid glycosides (1−5), each containing a caffeoyl group, a new flavonoid glycoside (10), and 14 known compounds (6−9and11−15, syringic acid, vanillic acid, phloretic acid, diplopterol, and β-sitosterol). This is the first report of phenylethanoid glycosides from the family Polypodiaceae. Compounds1−15were evaluated for their cancer chemopreventive potential based on their ability to inhibit tumor necrosis factor alpha (TNF-α)-induced NF-κB activity, nitric oxide (NO) production, and aromatase, quinone reductase 2 (QR-2), and COX-1/-2 activities. Quercetin-3-O-β-d-glucoside (15) demonstrated inhibition against QR2 with an IC50value of 3.84 μM, which confirmed kaempferol/quercetin glycosides as the active compounds to inhibit QR2. The compound also demonstrated NF-κB activity with an IC50value of 33.6 μM. In addition, compounds1,2,4, and6showed aromatase activity with IC50values of 30.7, 32.3, 26.8, and 35.3 μM, respectively.