Monitoring the Terahertz Response of Skin Beneath Transdermal Drug Delivery Patches Using Sparse Deconvolution
Monitoring the Terahertz Response of Skin Beneath Transdermal Drug Delivery Patches Using Sparse Deconvolution
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DOI：
10.1109/tthz.2023.3292546
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发表时间：
2023-09
影响因子：
3.2
通讯作者：
X. Barker;Gonçalo Costa;R. Stantchev;A. Hernandez-Serrano;Gabit Nurumbetov;D. Haddleton;E. Pickwell‐MacPherson
中科院分区：
文献类型：
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作者：
X. Barker;Gonçalo Costa;R. Stantchev;A. Hernandez-Serrano;Gabit Nurumbetov;D. Haddleton;E. Pickwell‐MacPherson
太赫兹（THz）光谱是一种非常有用的技术，由于其在测量水含量和非电离性质的高灵敏度，用于研究各种生物医学应用。通过将其与稀疏反卷积相结合，分离并重建透皮药物递送（TDD）贴片正下方皮肤的THz响应，以确定体内皮肤含水量。通过比较使用稀疏去卷积通过贴片测量的皮肤和使用标准方法处理的贴片去除后立即进行的皮肤测量，给出了该方法的验证。结果发现，具有非渗透性薄膜背衬的贴剂比具有渗透性编织聚酯纤维背衬的贴剂在更大程度上使皮肤水合，并且这种水合作用主要发生在贴剂贴敷的前30分钟内，并且在贴剂保持贴敷的情况下持续至少24小时。我们证明了这种稀疏重建方法的有效性，通过层，如补丁跟踪水化水平，并确定进一步的应用范围，包括TDD补丁开发和伤口愈合技术和监测。
Terahertz (THz) spectroscopy is a technique proving extremely useful for investigating various biomedical applications by virtue of its high sensitivity in the measurement of water content and its nonionizing nature. By combining this with sparse deconvolution, the THz response of skin directly underneath transdermal drug delivery (TDD) patches was isolated and reconstructed to determine the skin water content in vivo. Verification for this method was given by a comparison of skin measured through patches using sparse deconvolution and skin measurements immediately following patch removal processed with standard approaches. It was found that patches with a nonpermeable film backing hydrated the skin to a greater extent than permeable woven polyester fiber backed patches and that this hydration effect primarily occurs within the first 30 min of patch application and lasts for at least 24 h given that the patch remains applied. We demonstrate the effectiveness of this sparse reconstruction method to track hydration levels through layers such as patches and identify the scope for further applications including TDD patch development and wound healing techniques and monitoring.