Sickness and Aggressive Behavior in Dominant and Subordinate Mice
Sickness and Aggressive Behavior in Dominant and Subordinate Mice
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DOI：
10.1111/j.1439-0310.2008.01608.x
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发表时间：
2009-02-01
期刊：
影响因子：
1.7
通讯作者：
de Sa-Rocha, Luiz C.
中科院分区：
文献类型：
--
作者：
Cohn, Daniel W. H.;de Sa-Rocha, Luiz C.
生病的动物表现出一系列有组织的行为变化（疾病行为），这是整个行为的动机重组的结果。疾病行为表现可能受到社会环境的影响。在这项工作中，我们试图研究在一对小鼠的疾病行为在入侵者的存在下的调节。用细菌内毒素脂多糖（LPS）处理显性和从属小鼠，并在入侵小鼠的存在下进行攻击。LPS效应取决于排名和社会背景。即使占主导地位的小鼠对入侵者表现出更多的激动性相互作用，下属小鼠对入侵者表现出激动性行为时，其占主导地位的同伴与LPS治疗。结果表明，患病行为不仅在不同社会阶层之间表现出差异，而且患病行为与周围动物的不同反应有关。这些数据与疾病行为和社会行为之间关系的生物学方法有关。
Sick animals show a set of organized behavioral changes (sickness behavior), which is the result of a motivational re-organization of the behavior as a whole. Sickness behavior display can be influenced by the social context. In this work, we sought to investigate the regulation of sickness behavior within a pair of mice in the presence of an intruder mouse. Dominant and subordinate mice were treated with the bacterial endotoxin lipopolysaccharide (LPS) and were challenged with the presence of an intruder mouse. LPS effects depended on ranking and social context. Even though dominant mice displayed more agonistic interaction towards the intruder, subordinate mice displayed agonistic behavior towards the intruder when their dominant companion was treated with LPS. The results show that, not only sickness behavior is differentially expressed among different social ranks, but also that sickness behavior is related to different reactions among surrounding animals. These data are relevant for a biological approach to the relation between sickness behavior and social behavior.