HYPERURICEMIA AS A RISK FACTOR OF CORONARY HEART-DISEASE - THE FRAMINGHAM-STUDY
HYPERURICEMIA AS A RISK FACTOR OF CORONARY HEART-DISEASE - THE FRAMINGHAM-STUDY
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DOI：
10.1093/oxfordjournals.aje.a113972
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发表时间：
1985-01-01
影响因子：
5
通讯作者：
CASTELLI, WP
中科院分区：
文献类型：
--
作者：
BRAND, FN;MCGEE, DL;CASTELLI, WP
原始弗雷明汉队列的受试者在第四次和第十三次两年一次的检查中获得了尿酸值。第 4 次检查时男性的平均尿酸值为 5.0 mg/dl，第 13 次检查时的平均尿酸值为 5.7 mg/dl，女性的平均尿酸值分别为 3.9 mg/dl 和 4.7 mg/dl。这种长期趋势是由于实验室漂移和利尿剂使用的增加造成的。在两次检查中服用抗高血压药物的男女受试者中，血清尿酸值始终较高。男女血清尿酸值与收缩压和舒张压相关；女性中收缩压的相关性比舒张压的相关性更强。当使用更多的抗高血压治疗时，检查 4 的相关性比检查 13 的相关性更强。检查4血清尿酸一般可以预测冠心病的后续发展，特别是心肌梗塞，但不能预测心绞痛。尿酸与心肌梗塞的关系在男女中都同样强烈，甚至校正了抗高血压治疗。在包括年龄、收缩压、相对体重、吸烟和血清胆固醇在内的多变量分析中，血清尿酸并没有独立地增加冠心病的预测。
Uric acid values were obtained on subjects of the original Framingham cohort at their 4th and 13th biennial examinations. The mean uric acid value for men was 5.0 mg/dl at the 4th examination and 5.7 mg/dl at examination 13 and was 3.9 mg/dl and 4.7 mg/dl, respectively, for women. This secular trend was due to laboratory drift and increasing use of diuretics. Serum uric acid values were consistently higher in subjects of both sexes who were taking antihypertensive drugs at both examinations. Serum uric acid values correlated with systolic and diastolic blood pressure in both sexes; the relationship was stronger in women and for systolic than for diastolic pressure. Correlations were stronger at examination 4 than at examination 13 when more antihypertensive treatment was used. Examination 4 serum uric acid predicted the subsequent development of coronary heart disease, in general, and myocardial infarction, in particular, but not angina pectoris. The uric acid relationship with myocardial infarction was equally strong in both sexes, even correcting for antihypertensive treatment. In multivariate analysis, including age, systolic blood pressure, relative weight, cigarette smoking and serum cholesterol, serum uric acid did not add independently to the prediction of coronary heart disease.