Specific organ metastases and survival in small cell lung cancer
Specific organ metastases and survival in small cell lung cancer
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DOI：
10.3892/ol.2012.792
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发表时间：
2012-10-01
期刊：
影响因子：
2.9
通讯作者：
Hizawa, Nobuyuki
中科院分区：
文献类型：
--
作者：
Nakazawa, Kensuke;Kurishima, Koichi;Hizawa, Nobuyuki
本回顾性研究的目的是评估与小细胞肺癌远处转移相关的临床病理特征。我们回顾了1999年至2010年期间诊断为小细胞肺癌转移的患者。在连续诊断的251例SCLC患者中，152例（60.6%）患者发生远处转移，其中肝、骨、脑、肺和肾上腺转移分别占20.3%、18.3%、15.5%、10.0%和6.0%。采用考克斯比例风险模型进行多变量分析，我们发现肝、骨和脑转移以及胸腔积液和/或心包积液是不利的预后因素。而肺、肾上腺和胸外淋巴结转移则不是显著的预后因素。对于小细胞肺癌患者的治疗，特别是那些有肝，骨和脑转移或胸腔和/或心包液，我们应该考虑转移器官。
The aim of our retrospective study was to evaluate the clinicopathological features associated with distant metastasis from small cell lung cancer (SCLC). We reviewed patients diagnosed with SCLC metastasis at the time of presentation between 1999 and 2010. Among the consecutive 251 SCLC patients diagnosed, 152 (60.6%) patients had distant metastasis, of which 20.3, 18.3, 15.5, 10.0 and 6.0% of patients had liver, bone, brain, lung and adrenal gland metastasis, respectively. In a multivariate analysis using Cox's proportional hazards model, we identified that liver, bone and brain metastasis as well as the presence of pleural and/or pericardial fluids were unfavorable prognostic factors. However, lung, adrenal gland and extrathoracic lymph node metastasis were not statistically significant prognostic factors. With regard to the treatment of SCLC patients, particularly those with liver, bone and brain metastasis or pleural and/or pericardial fluids, we should take the metastasizing organs into consideration.