Enantioselective nitrone cycloadditions of α,β-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl)pyridine-cerium(IV) triflate complexes
Enantioselective nitrone cycloadditions of α,β-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl)pyridine-cerium(IV) triflate complexes
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DOI：
10.1021/ol061223i
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发表时间：
2006-07-20
期刊：
影响因子：
5.2
通讯作者：
Fandrick, Keith R.
中科院分区：
文献类型：
--
作者：
Evans, David A.;Song, Hyun-Ji;Fandrick, Keith R.
报道了双恶唑啉吡啶-三氟甲磺酸铈配合物1催化硝酮与β-取代α，β-不饱和2-酰基咪唑的不对称环加成反应。异恶唑烷产物被有效地转化为密集官能化的β ′-羟基-β-氨基酸衍生物。
Enantioselective nitrone cycloadditions with, ss-substituted alpha,ss-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl) pyridine-cerium(IV) triflate complexes 1 have been reported. The isoxazolidine products were efficiently transformed into densely functionalized, ss'- hydroxy-ss-amino acid derivatives.