Combination chemotherapy with carboplatin and bleomycin for advanced and recurrent head and neck cancer: A phase II study
Combination chemotherapy with carboplatin and bleomycin for advanced and recurrent head and neck cancer: A phase II study
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卡铂和博来霉素联合化疗治疗晚期和复发性头颈癌：一项 II 期研究
DOI：
10.1002/jso.2930390318
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发表时间：
1988
影响因子：
2.5
通讯作者：
R. Margolese
中科院分区：
文献类型：
--
作者：
J. González;L. Panasci;M. Black;Michael Pollak;R. Margolese
卡铂是一种铂类似物，据报道在头颈癌中具有活性。我们对14名复发性头颈癌患者进行了II期试验。卡铂300 mg/m2静脉滴注（I. V.）博莱霉素30单位每四周静脉注射一次在该组患者中未观察到缓解。卡铂给药的剂量强度可能是反应的重要决定因素。
Carboplatin is a platinum analogue with activity reported in head and neck cancer. We conducted a phase II trial with 14 patients who had recurrent head and neck cancer. They were treated with carboplatin 300 mg/m2 intravenously (I.V.) and bleomycin 30 units I.V. every 4 weeks. No responses were observed in this group of patients. Dose intensity of carboplatin administration may be an important determinant of response.