Obsessive-compulsive symptom dimensions correlate to specific gray matter volumes in treatment-naive patients
Obsessive-compulsive symptom dimensions correlate to specific gray matter volumes in treatment-naive patients
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DOI：
10.1016/j.jpsychires.2012.09.002
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发表时间：
2012-12-01
影响因子：
4.8
通讯作者：
Hoexter, Marcelo Q.
中科院分区：
文献类型：
--
作者：
Alvarenga, Pedro G.;do Rosario, Maria C.;Hoexter, Marcelo Q.
背景资料：临床和社会人口学研究结果支持强迫症是异质性的，由多个潜在的重叠和稳定的症状维度组成。以前的神经影像学研究相关的不同模式的强迫症维度分数和灰质（GM）的体积。尽管他们的相关贡献，一些方法的局限性，如患者以前的药物摄入量，可能会导致不一致的findings.Method：基于体素的形态测量被用来调查区域GM体积和症状维度严重程度评分之间的相关性在一个样本中的38个治疗初治强迫症患者。几个标准化的工具，包括一个专门开发用于评估症状维度的严重程度（DY-BOCS）的采访。结果：得分的“侵略”的尺寸呈正相关，在两侧半球的侧顶叶皮质的GM体积呈负相关，与双侧小脑，左壳核和左下眶额皮层。“性/宗教”维度得分与右侧中外侧OFC和右侧DLPFC的GM体积呈正相关，与双侧ACC呈负相关。“囤积”维度得分与左侧上级外侧OFC的GM体积呈正相关，与右侧海马旁回呈负相关。GM体积和“污染”或“对称”尺寸之间没有显着的相关性被发现。结论：建立在先前存在的研究结果，我们的数据与治疗幼稚强迫症患者表现出不同的GM基板涉及在不同的OCS尺寸的认知和情感处理。(C)2012爱思唯尔有限公司保留所有权利。
Background: Clinical and sociodemographic findings have supported that OCD is heterogeneous and composed of multiple potentially overlapping and stable symptom dimensions. Previous neuroimaging investigations have correlated different patterns of OCD dimension scores and gray matter (GM) volumes. Despite their relevant contribution, some methodological limitations, such as patient's previous medication intake, may have contributed to inconsistent findings.Method: Voxel-based morphometry was used to investigate correlations between regional GM volumes and symptom dimensions severity scores in a sample of 38 treatment-naive OCD patients. Several standardized instruments were applied, including an interview exclusively developed for assessing symptom dimensions severity (DY-BOCS).Results: Scores on the "aggression" dimension were positively correlated with GM volumes in lateral parietal cortex in both hemispheres and negatively correlated with bilateral insula, left putamen and left inferior OFC. Scores on the "sexual/religious" dimension were positively correlated with GM volumes within the right middle lateral OFC and right DLPFC and negatively correlated with bilateral ACC. Scores on the "hoarding" dimension were positively correlated with GM volumes in the left superior lateral OFC and negatively correlated in the right parahippocampal gyrus. No significant correlations between GM volumes and the "contamination" or "symmetry" dimensions were found.Conclusions: Building upon preexisting findings, our data with treatment-naive OCD patients have demonstrated distinct GM substrates implicated in both cognitive and emotion processing across different OCS dimensions. (C) 2012 Elsevier Ltd. All rights reserved.