Imaging of dopamine transporters with iodine-123-beta-CIT and SPECT in Parkinson's disease.
Imaging of dopamine transporters with iodine-123-beta-CIT and SPECT in Parkinson's disease.
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使用 i-123-beta-CIT 和 SPECT 对帕金森病中的多巴胺转运蛋白进行成像。
DOI：
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发表时间：
1997
影响因子：
9.3
通讯作者：
L. Deecke
中科院分区：
文献类型：
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作者：
S. Asenbaum;T. Brücke;W. Pirker;I. Podreka;P. Angelberger;S. Wenger;C. Wöber;Christian Müller;L. Deecke
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本研究的目的是通过使用可卡因衍生物[123I]β-CIT（2-β-甲氧基-3-β（4-碘苯基）-托烷或RTI-55）和SPECT来证明帕金森病中多巴胺能黑质纹状体通路的变性，并将研究结果与疾病的严重程度（Hoehn和Yahr量表，H/Y）以及运动评分和活动等临床数据联系起来的日常生活。
方法
对 13 名志愿者和 47 名 H/Y I-V 期特发性帕金森病 (PD) 患者（I:n = 16、II:n = 6、III:n = 14、IV:n = 9、V:n = 2）进行了研究。注射后2、4、16、20和24小时进行采集。在纹状体和小脑上绘制 ROI。特异性 β-CIT 结合被定义为纹状体减去小脑结合。确定特异性结合与不可置换结合（纹状体/小脑-1）的比率，以及该比率与预期年龄对照值的百分比偏差。
结果
纹状体 [123I]β-CIT 结合的时间-活性曲线显示，对照组在注射后 20 小时左右达到最大值，在 PD 患者中在注射后 4 小时达到峰值。两组之间的比率存在显着差异。该比率与临床指标之间存在显着相关性。偏侧帕金森病患者的[123I]β-CIT结合显着减少，不仅是临床受影响侧的对侧，而且是临床未受影响侧的对侧。与年龄预期值相比，[123I]beta-CIT 结合显着下降，范围从 H/Y 1 期的 36% 到 H/Y V 期的 71%。
结论
本研究表明，使用 [123I]beta-CIT 和 SPECT 可以可视化和量化 PD 中多巴胺能黑质纹状体神经元的变性，并且与临床参数具有良好的相关性。
UNLABELLED
The aim of the present study was to demonstrate the degeneration of the dopaminergic nigrostriatal pathway in Parkinson's disease by using the cocaine derivative [123I]beta-CIT (2-beta-carbomethoxy-3-beta(4-iodophenyl)-tropane or RTI-55) and SPECT and to relate the findings to the severity of the disease (Hoehn and Yahr scale, H/Y) and to clinical data such as motor score and activities of daily living.
METHODS
Thirteen volunteers and 47 patients with idiopathic Parkinson's disease (PD) of H/Y Stage I-V (I:n = 16, II:n = 6, III:n = 14, IV:n = 9, V:n = 2) were investigated. Acquisitions were performed 2, 4, 16, 20 and 24 hr postinjection. ROIs were drawn over the striatum and the cerebellum. Specific beta-CIT binding was defined as striatal minus cerebellar binding. The ratio of specific over nondisplaceable binding (striatum/cerebellum-1) was determined as well as the percent deviation of this ratio from age-expected control values.
RESULTS
The time-activity curve of striatal [123I]beta-CIT binding demonstrated a maximum around 20 hr postinjection in controls and a peak 4 hr postinjection in PD patients. Ratios differed significantly between the two groups. A significant correlation existed between this ratio and clinical measures. Hemiparkinsonian patients revealed significantly diminished [123I]beta-CIT binding not only contralateral to the clinically affected but also contralateral to the clinically unaffected side. [123I]beta-CIT binding showed a significant decrease in comparison to age-expected values ranging from 36% in H/Y stage 1 to 71% in H/Y stage V.
CONCLUSION
The present study demonstrates that it is possible to visualize and quantify the degeneration of dopaminergic nigrostriatal neurons in PD using [123I]beta-CIT and SPECT with good correlation to clinical parameters.
在相同条件下，在大鼠纹状体突触体制备物中测量多巴胺的易位和 2β-甲氧甲氧基-3β-(4-氟苯基)托烷 (WIN 35,428) 的结合。
影响因子：
5.8
作者：
Xu,C;Coffey,LL;Reith,ME
通讯作者：
Reith,ME