Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases
Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases
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DOI：
10.1192/bjp.187.6.510
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发表时间：
2005-12-01
影响因子：
10.5
通讯作者：
Munk-Jorgensen, P
中科院分区：
文献类型：
--
作者：
Arendt, M;Rosenberg, R;Munk-Jorgensen, P
背景很少有研究已经检查了大麻引起的精神病symptoms.Aims的人的样本，以确定是否大麻引起的精神病性障碍是由持续的精神病性条件的发展，以及其onset.Method的时间，1994年和1999年之间的大麻引起的精神病性症状治疗的患者的数据提取自丹麦精神病学中央登记。排除了先前因任何精神病症状接受过治疗的患者。其余535例患者至少随访3年。在一个单独的分析中，样本进行了比较，第一次提到精神分裂症谱系障碍的人，但谁没有大麻引起的psychosis.Results精神分裂症谱系障碍的历史被诊断为44.5%的样本。在77.2%的患者中诊断出任何类型的新精神病发作。男性和年轻与风险增加有关。精神分裂症谱系障碍的发展往往被推迟，47.1%的患者在寻求大麻诱导的精神病治疗后一年多才得到诊断。患者发展为精神分裂症在较早的年龄比人在对照组（男性，24.6 v. 30.7岁，女性，28.9 v. 33.1岁）。结论大麻引起的精神障碍是非常重要的临床和预后。
Background Few studies have examined samples of people with cannabis-induced psychotic symptoms.Aims To establish whether cannabis-induced psychotic disorders are followed by development of persistent psychotic conditions, and the timing of their onset.Method Data on patients treated for cannabis-induced psychotic symptoms between 1994 and 1999 were extracted from the Danish Psychiatric Central Register. Those previously treated for any psychotic symptoms were excluded. The remaining 535 patients were followed for at least 3 years. In a separate analysis, the sample was compared with people referred for schizophrenia-spectrum disorders for the first time, but who had no history of cannabis-induced psychosis.Results Schizophrenia-spectrum disorders were diagnosed in 44.5% of the sample. New psychotic episodes of any type were diagnosed in 77.2%. Male gender and young age were associated with increased risk. Development of schizophrenia-spectrum disorders was often delayed, and 47.1% of patients received a diagnosis more than a year after seeking treatment for a cannabis-induced psychosis. The patients developed schizophrenia at an earlier age than people in the comparison group (males, 24.6 v. 30.7 years, females, 28.9 v. 33.1 years).Conclusions Cannabis-induced psychotic disorders are of great clinical and prognostic importance.Declaration of interest None.