Oral contraceptive use and early abortion as risk factors for breast cancer in young women.
Oral contraceptive use and early abortion as risk factors for breast cancer in young women.
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DOI：
10.1038/bjc.1981.10
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发表时间：
1981-01
影响因子：
8.8
通讯作者：
Gray GE
中科院分区：
文献类型：
--
作者：
Pike MC;Henderson BE;Casagrande JT;Rosario I;Gray GE
在加利福尼亚州洛杉矶县进行了一项病例对照研究，对163例非常年轻的乳腺癌病例(确诊时年龄均在32岁或以下)进行了研究，以调查口服避孕药(OC)在疾病发展中的作用。在第一次足月妊娠前使用OC与风险增加有关，这种风险随着使用OC的时间的延长而增加(使用6年的相对风险约为2.2，P<；0.01)。这种增加的风险无法用其他风险因素来解释。在Fftp后使用OC与风险的任何变化无关。妊娠早期流产，无论是自然流产还是引产，都与乳腺癌风险增加2.4%有关(P<；0.005)。
A case-control study was conducted in Los Angeles County, California, of 163 very young breast-cancer cases (all aged 32 or less at diagnosis) to investigate the role, if any, of oral contraceptives (OC) in the development of the disease. OC use before first full-term pregnancy (FFTP) was associated with an elevated risk, which increased with duration of OC use (relative risk approximately 2.2 at 6 years of use, P < 0.01). This increased risk could not be explained by other risk factors. OC use after FFTP was not associated with any change in risk. A first-trimester abortion before FFTP, whether spontaneous or induced, was associated with a 2.4-fold increase in breast-cancer risk (P < 0.005).