A Novel Useful Tool of Computerized Touch Panel-Type Screening Test for Evaluating Cognitive Function of Chronic Ischemic Stroke Patients
A Novel Useful Tool of Computerized Touch Panel-Type Screening Test for Evaluating Cognitive Function of Chronic Ischemic Stroke Patients
复制标题
DOI：
10.1016/j.jstrokecerebrovasdis.2012.11.011
复制
发表时间：
2013-10-01
影响因子：
2.5
通讯作者：
Abe, Koji
中科院分区：
文献类型：
--
作者：
Deguchi, Kentaro;Kono, Syoichiro;Abe, Koji
认知和情感障碍是与白质高信号（包括室周高信号（PVH））相关的缺血性卒中（IS）的重要非运动特征。为了证实一种新的计算机触摸面板式筛选测试的有用性，我们调查了142名IS患者和105名年龄和性别匹配的正常对照组的认知和情感功能。使用简易精神状态检查、长谷川痴呆量表修订版和额叶评估组合进行的评估显示，IS患者的认知功能降低，心源性栓塞患者表现出最严重的降低，其次是腔隙性梗死患者和动脉粥样硬化血栓性梗死患者。我们的新型触摸屏筛选测试显示了类似的结果模式。此外，使用Fazekas的磁共振成像方法分类的PVH分级也与认知能力下降和触摸屏筛选测试表现相关。相反，用15项老年抑郁量表、活力指数和冷漠量表评估的情感功能在IS中没有显著降低，并且与触摸屏筛查试验结果或PVH无关，尽管微出血数量与冷漠量表结果相关。目前的研究结果显示，IS和PVH分级与一般认知状态（简易精神状态检查和长谷川痴呆量表修订版）和额叶功能（额叶评估电池）的下降显着相关。所有触摸屏筛查测试的表现与IS和PVH分级相关，但在很大程度上独立于抑郁或冷漠。触摸屏筛查测试很容易理解，几乎所有轻度认知和运动功能障碍的患者都可以进行，这是由于视觉清晰的图像和简单的方法，不涉及详细的手动操作任务，如书写。触摸屏筛查试验可能为认知功能的早期筛查提供有用的工具。
Cognitive and affective impairments are important non-motor features of ischemic stroke (IS) related to white-matter hyperintensity, including periventricular hyperintensity (PVH). To confirm the usefulness of a novel computerized touch panel-type screening test, we investigated cognitive and affective functioning among 142 IS patients and 105 age-and gender-matched normal control subjects. Assessment using the mini-mental state examination, Hasegawa Dementia Scale-Revised, and frontal assessment battery revealed reduced cognitive function in IS patients, with the most severe reduction exhibited by cardiogenic embolism patients, followed by lacunar infarction patients, and atherothrombotic infarction patients. Our novel touch panel screening test revealed a similar pattern of results. In addition, PVH grading, classified using Fazekas' magnetic resonance imaging method, was also correlated with cognitive decline and touch panel screening test performance. In contrast, affective function, assessed with the 15-item Geriatric Depression Scale, vitality index, and apathy scale, was not significantly decreased in IS, and did not correlate with touch panel screening test results or PVH, although the number of microbleeds was correlated with apathy scale results. The present findings revealed that IS and PVH grading were significantly correlated with decline in general cognitive status (mini-mental state examination and Hasegawa Dementia Scale-Revised) and frontal lobe function (frontal assessment battery). Performance on all touch panel screening tests was correlated with IS and PVH grading, but was largely independent of depression or apathy. Touch panel screening tests were easily understood and performed by almost all patients with mild cognitive and motor dysfunction, due to visually clear images and simple methods not involving detailed manual-handling tasks such as writing. Touch panel screening tests may provide a useful tool for the early screening of cognitive function.