Evolving understanding of translocator protein 18 kDa (TSPO).
Evolving understanding of translocator protein 18 kDa (TSPO).
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DOI：
10.1016/j.phrs.2015.03.022
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发表时间：
2015-09
影响因子：
9.3
通讯作者：
Ferguson-Miller S
中科院分区：
文献类型：
--
作者：
Li F;Liu J;Garavito RM;Ferguson-Miller S
易位蛋白 18 kD (TSPO) 因其明显参与许多疾病相关过程而成为生物医学界和制药行业深入研究的焦点。这些包括类固醇生成、细胞凋亡、炎症、神经系统疾病和癌症，导致 TSPO 作为生物标志物的使用及其作为药物靶点的潜力。尽管经过 30 多年的研究，TSPO 的确切功能仍然难以捉摸。最近在确定线粒体 TSPO 细菌同源物的高分辨率晶体结构方面取得的突破，为分子水平上的结构和功能特性提供了新的见解，并为研究这一古老且高度保守的蛋白质家族的重要性提供了新的机会。来自不同物种的原子级结构信息的可用性也为基于结构的药物开发提供了平台。在这里，我们简要回顾了有关 TSPO 的当前知识以及新结构对该领域的假设和争议的影响。
The translocator protein 18 kD (TSPO) has been the focus of intense research by the biomedical community and the pharmaceutical industry because of its apparent involvement in many disease-related processes. These include steroidogenesis, apoptosis, inflammation, neurological disease and cancer, resulting in the use of TSPO as a biomarker and its potential as a drug target. Despite more than 30 years of study, the precise function of TSPO remains elusive. A recent breakthrough in determining the high-resolution crystal structures of bacterial homologs of mitochondrial TSPO provides new insight into the structural and functional properties at a molecular level and new opportunities for investigating the significance of this ancient and highly conserved protein family. The availability of atomic level structural information from different species also provides a platform for structure-based drug development. Here we briefly review current knowledge regarding TSPO and the implications of the new structures with respect to hypotheses and controversies in the field.