Clinical significance of abnormal heterogeneity of transferrin in relation to alcohol consumption.
Clinical significance of abnormal heterogeneity of transferrin in relation to alcohol consumption.
复制标题
转铁蛋白异常异质性与饮酒相关的临床意义。
作者：
Helena Stibler;Stefan Borg;C. Allgulander
本文用等电聚焦和直接免疫固定法对98例酒精中毒患者、22例肝病患者和100例正常人血清转铁蛋白中的一种异常微量异质组分进行了研究。在健康志愿者中研究了其与急性和长期乙醇摄入的关系。发现异常转铁蛋白组分是长期高酒精摄入的敏感指标，并且在81%的入院消耗超过60 g乙醇/天的患者中观察到，并且在至少10天的禁欲后恢复正常。它发生在1%的对照组中，并且在没有当前酒精滥用的肝病病例中没有发生。有证据表明，在异常转铁蛋白中唾液酸含量减少。在许多其他糖蛋白中没有发现类似的变化。这项测试可能是一个有用的和敏感的工具，用于检测慢性酒精消费。
An abnormal microheterogeneous component of serum transferrin, with a higher isoelectric point than the normal main component, was studied by means of isoelectric focusing and direct immunofixation in 98 alcoholic patients, 22 patients with liver diseases and 100 controls. Its relation to acute and prolonged ethanol intake was studied in healthy volunteers. The abnormal transferrin component was found to be a sensitive indicator of prolonged, high alcohol ingestion, and was observed in 81% of patients with an admitted consumption of more than 60 g ethanol/day, and normalized after at least 10 days of abstinence. It occurred in 1% of the controls and in none of the cases with liver diseases without current alcohol abuse. There is evidence of a reduced sialic acid content in the abnormal transferrin. No similar change has been found in a number of other glycoproteins. This test may be a useful and sensitive tool for the detection of chronic alcohol consumption.