Extraordinary diversity in vasopressin (V1a) receptor distributions among wild prairie voles (Microtus ochrogaster):: Patterns of variation and covariation
Extraordinary diversity in vasopressin (V1a) receptor distributions among wild prairie voles (Microtus ochrogaster):: Patterns of variation and covariation
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DOI：
10.1002/cne.10902
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发表时间：
2003-11-24
影响因子：
2.5
通讯作者：
Young, LJ
中科院分区：
文献类型：
--
作者：
Phelps, SM;Young, LJ
加压素V1 a受体是一种已知的基因，它对社会行为中的物种差异至关重要，包括一夫一妻制草原田鼠与其滥交同类之间的差异。为了研究个体差异与物种差异的比较，我们在一个大样本的野生草原田鼠的血管加压素V1 a受体（V1 aR）的表达的特点的变化。我们发现了一个令人惊讶的程度的种内变异V1 aR结合，似乎并不归因于实验来源。大多数大脑区域表现出上四分位数和下四分位数之间的差异，这些差异与本属物种之间的差异相当。区域的变化较小，以前曾涉及调节一夫一妻制的行为，这表明在这些网站缺乏变化可能反映自然选择交配系统。许多大脑区域都有很强的共变性。协变的总体模式反映了大脑区域的发育起源。这一发现表明，共同的转录调控机制可能会限制基因表达的模式。这种偏见可能会影响选择的效力以及个体和物种差异的模式。总的来说，我们的数据表明，草原田鼠将是一个有用的模型，探索基因表达的个体差异如何影响复杂的社会行为。(C)2003 Wiley-Liss，Inc.
The vasopressin V1a receptor is a gene known to be central to species differences in social behavior, including differences between the monogamous prairie vole and its promiscuous congeners. To examine how individual differences compare with species differences, we characterize variability in the expression of the vasopressin V1a receptor (V1aR) in a large sample of wild prairie voles. We find a surprising degree of intraspecific variation in V1aR binding that does not seem attributable to experimental sources. Most brain regions exhibit differences between upper and lower quartiles that are comparable to differences between species in this genus. Region's that are less variable have been implicated previously in regulating monogamous behaviors, suggesting that the lack of variation at these sites could reflect natural selection on mating system. Many brain regions covary strongly. The overall pattern of covariation reflects the developmental origins of brain regions. This finding suggests that shared mechanisms of transcriptional regulation may limit the patterns of gene expression. Such biases may shape both the efficacy of selection and the pattern of individual and species differences. Overall, our data indicate that the prairie vole would be a useful model for exploring how individual differences in gene expression influence complex social behaviors. (C) 2003 Wiley-Liss, Inc.