Gene regulation by chromatin structure: paradigms established in Drosophila melanogaster.
Gene regulation by chromatin structure: paradigms established in Drosophila melanogaster.
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DOI：
10.1146/annurev.ento.51.110104.151007
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发表时间：
2007
影响因子：
23.8
通讯作者：
S. Schulze;L. Wallrath
中科院分区：
文献类型：
--
作者：
S. Schulze;L. Wallrath
Studies in Drosophila melanogaster have revealed paradigms for regulating gene expression through chromatin structure, including mechanisms of gene activation and silencing. Regulation occurs at the level of individual genes, chromosomal domains, and entire chromosomes. The chromatin state is dynamic, allowing for changes in gene expression in response to cellular signals and/or environmental cues. Changes in chromatin result from the action of ATP-dependent chromatin-remodeling complexes, reversible epigenetic histone modifications, and the incorporation of histone variants. Many of the chromatin-based transcriptional regulatory mechanisms discovered in D. melanogaster are evolutionarily conserved and therefore serve as a foundation for studies in other organisms.
