Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing.
Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing.
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DOI：
10.1016/j.tig.2013.05.001
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发表时间：
2013-08
期刊：
影响因子：
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通讯作者：
S. Yamazaki;Motoshi Hayano;H. Masai
中科院分区：
文献类型：
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作者：
S. Yamazaki;Motoshi Hayano;H. Masai
真核生物基因组上的DNA复制起点已被观察到在S期以协调的方式启动。在酵母中的研究表明，起源发射受几个因素的影响，包括检查点调节剂和染色质修饰剂。然而，尚不清楚协调这一协调进程的机制是什么。最近的研究已经确定了调节起始激活时间的因素，包括Rif1，它在酵母和高等真核生物中的复制时间程序的调节中起着至关重要的作用。在哺乳动物细胞中，Rif1似乎通过其组织染色质环结构的能力来调节复制时序结构域的结构。Rif1对染色质结构的调节可能与其他染色体的处理有关，包括重组、修复或转录。本文综述了真核生物复制子复制时间调控机制的研究进展。
Origins of DNA replication on eukaryotic genomes have been observed to fire during S phase in a coordinated manner. Studies in yeast indicate that origin firing is affected by several factors, including checkpoint regulators and chromatin modifiers. However, it is unclear what the mechanisms orchestrating this coordinated process are. Recent studies have identified factors that regulate the timing of origin activation, including Rif1 which plays crucial roles in the regulation of the replication timing program in yeast as well as in higher eukaryotes. In mammalian cells, Rif1 appears to regulate the structures of replication timing domains through its ability to organize chromatin loop structures. Regulation of chromatin architecture by Rif1 may be linked to other chromosome transactions including recombination, repair, or transcription. This review summarizes recent progress in the effort to elucidate the regulatory mechanisms of replication timing of eukaryotic replicons.