Recent consumption of a caffeine-containing beverage and serum biomarkers of cardiometabolic function in the UK Biobank.
Recent consumption of a caffeine-containing beverage and serum biomarkers of cardiometabolic function in the UK Biobank.
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DOI：
10.1017/s0007114520004377
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发表时间：
2021-08-28
期刊：
影响因子：
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通讯作者：
Cornelis MC
中科院分区：
文献类型：
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作者：
Cornelis MC
我们调查了在自由生活条件下，近期咖啡因饮用对葡萄糖和其他心脏代谢功能生物标志物的影响，同时也考虑了改变咖啡因代谢和饮酒行为的生活方式和遗传因素。2006-2010年，447794名年龄在37-73岁之间的英国生物银行参与者提供了非空腹血液样本，用于基因和生物标志物测量，并完成了关于社会人口统计学、病史和生活方式的问卷调查。采集血液前约一小时的咖啡因饮用（是/否）也被记录下来。使用多变量回归来检验近期饮用咖啡因与糖化血红蛋白、葡萄糖、脂质、载脂蛋白、脂蛋白-a和c反应蛋白的血清水平之间的关系。报告最近饮用咖啡因的男性和女性的临床血糖水平明显高于那些最近没有饮用咖啡因的人（P<0.0001）。在55岁以上、肥胖程度较高、禁食时间较长的人群中观察到更大的效应（相互作用的P≤0.02）。在女性中观察到显著的CYP1A2 rs2472297×caffeine和MLXIPL rs7800944×caffeine对血糖水平的相互作用（P=0.004），在男性中观察到类似但不显著的相互作用。rs2472297 CC或rs7800944 CC基因型的女性分别比rs2472297 T或rs7800944 T携带者的效应更大。总之，在抽血后1小时内饮用咖啡因的男性和女性的血糖水平高于不饮用咖啡因的人。研究结果受到年龄、肥胖、禁食时间和与咖啡因代谢和饮酒行为相关的遗传因素的影响。对含咖啡因饮料和心脏代谢健康的临床和人群研究的意义进行了讨论。
We investigated the impact of recent caffeine drinking on glucose and other biomarkers of cardiometabolic function under free-living conditions while also accounting for lifestyle and genetic factors that alter caffeine metabolism and drinking behavior. Up to 447,794 UK Biobank participants aged 37–73 years in 2006–2010 provided a non-fasting blood sample, for genetic and biomarker measures, and completed questionnaires regarding sociodemographics, medical history and lifestyle. Caffeine drinking (yes/no) about an hour before blood collection was also recorded. Multivariable regressions were used to examine the association between recent caffeine drinking and serum levels of glycated haemoglobin, glucose, lipids, apolipoproteins, lipoprotein-a, and C-reactive protein. Men and women reporting recent caffeine drinking had clinically and significantly higher glucose levels than those not recently drinking caffeine (P<0.0001). Larger effects sizes were observed among those 55+ years of age and with higher adiposity and longer fasting times (P≤0.02 for interactions). Significant CYP1A2 rs2472297×caffeine and MLXIPL rs7800944×caffeine interactions on glucose levels were observed among women (P=0.004), with similar but non-significant interactions in men. Larger effects sizes were observed among women with rs2472297 CC or rs7800944 CC genotypes than among rs2472297 T or rs7800944 T carriers, respectively. In summary, men and women drinking caffeine within ~1 hour of blood draw had higher glucose levels than those not drinking caffeine. Findings were modified by age, adiposity, fasting time and genetic factors related to caffeine metabolism and drinking behavior. Implications for clinical and population studies of caffeine-containing beverages and cardiometabolic health are discussed.