Association between age at menarche and cardiometabolic risk among Samoan adults.
Association between age at menarche and cardiometabolic risk among Samoan adults.
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萨摩亚成年人初潮年龄与心脏代谢风险之间的关联。
DOI：
10.1002/ajhb.23982
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Hawley,NicolaL
中科院分区：
文献类型：
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作者：
Oyama,Sakurako;Duckham,RachelL;Pomer,Alysa;Rivara,AnnaC;Kershaw,ErinE;Wood,Ashlee;Fidow,UlaiT;Naseri,Take;Reupena,MuagututiaS;Viali,Satupaitea;McGarvey,StephenT;Hawley,NicolaL
目的最近的研究表明，月经初潮早期可能增加心脏代谢性疾病的发病率和死亡率。然而，在肥胖率位居全球前列的太平洋岛屿，很少有研究研究这种联系。我们试图检查月经初潮年龄和萨摩亚心脏代谢风险之间的关系。方法参与者来自于2017年至2019年在萨摩亚进行的Soifua Manuia研究(n= 285，年龄32-72 )。采用Logistic回归分析估计月经初潮年龄每增加一年患肥胖症、高血压、糖尿病、血脂异常和代谢综合征的几率。对初潮年龄与连续测量肥胖、血压、胰岛素抵抗和血脂的相关性进行线性回归分析。结果初潮年龄中位数为14 (IQR = 2)。在控制了相关的协变量后，初潮年龄每增加一年，患高血压的几率降低15%(OR = 0.85，95%CI：0.72-1.01，p= .067)，患糖尿病的几率增加21%(OR = 1.21，95%CI：1.01-1.45，p= .044)，患高总胆固醇的几率增加18%(OR = 1.18，95%CI：0.98-1.42，p= .081)。月经初潮年龄每增加一年，瘦体重减少1.60 ± 0.52 kg(p= .002)，脱脂体重减少1.56 ± 0.51 kg(p= .003)。需要前瞻性研究来阐明儿童肥胖和其他早期生活暴露对月经初潮年龄和随后的心脏代谢风险的作用。
ObjectivesRecent studies suggest that early menarche may increase cardiometabolic morbidity and mortality. Yet few studies have examined this association in the Pacific Islands, where obesity prevalence is among the highest globally. We sought to examine associations between age at menarche and cardiometabolic risk in Samoa.MethodsParticipants were from theSoifua Manuiastudy (n= 285, age 32–72 years) conducted in Samoa from 2017 to 2019. Logistic regressions were conducted to estimate odds of obesity, hypertension, diabetes, dyslipidemia, and metabolic syndrome per one‐year increase in age at menarche. Linear regressions were conducted to examine associations between age at menarche and continuous measures of adiposity, blood pressure, insulin resistance, and serum lipids.ResultsMedian age at menarche was 14 years (IQR = 2). After controlling for relevant covariates, each one‐year increase in age at menarche was associated with a 15% decrease (OR = 0.85, 95% CI: 0.72–1.01,p= .067) in odds of hypertension, but a 21% increase (OR = 1.21, 95% CI: 1.01–1.45,p= .044) in odds of diabetes and 18% increase (OR = 1.18, 95% CI: 0.98–1.42,p= .081) in odds of high total cholesterol. Each additional year in age at menarche was associated with a 1.60 ± 0.52 kg (p= .002) decrease in lean mass and 1.56 ± 0.51 kg (p= .003) decrease in fat‐free mass.ConclusionsAssociations between age at menarche and cardiometabolic risk may be population‐specific and are likely influenced by both current and historical nutritional and epidemiological contexts. Prospective studies are needed to clarify the role of childhood adiposity and other early life exposures on age at menarche and subsequent cardiometabolic risk.