CD-Search: protein domain annotations on the fly
CD-Search: protein domain annotations on the fly
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DOI：
10.1093/nar/gkh454
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发表时间：
2004-07-01
影响因子：
14.9
通讯作者：
Bryant, SH
中科院分区：
文献类型：
--
作者：
Marchler-Bauer, A;Bryant, SH
我们描述了保守域搜索服务（CD-Search），一个基于网络的工具，用于检测蛋白质序列的结构和功能域。CD-Search使用BLAST(R)启发式提供快速、交互式的服务，并搜索领域模型的综合集合。搜索结果显示为领域架构卡通以及查询和领域模型一致性序列之间的成对对齐。通过将查询序列嵌入到多个比对显示中，并将其映射到域族内已知结构的三维分子图形显示中，可以更详细地可视化搜索结果。CD-Search可以访问http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi。
We describe the Conserved Domain Search service (CD-Search), a web-based tool for the detection of structural and functional domains in protein sequences. CD-Search uses BLAST(R) heuristics to provide a fast, interactive service, and searches a comprehensive collection of domain models. Search results are displayed as domain architecture cartoons and pairwise alignments between the query and domain-model consensus sequences. Search results may be visualized in further detail by embedding the query sequence into multiple alignment displays and by mapping onto three-dimensional molecular graphic displays of known structures within the domain family. CD-Search can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi.