Glycopolymers and glyco-nanoparticles in biomolecular recognition processes and vaccine development.
Glycopolymers and glyco-nanoparticles in biomolecular recognition processes and vaccine development.
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DOI：
10.1002/mabi.201200222
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发表时间：
2013
影响因子：
4.6
通讯作者：
Rajesh Sunasee;R. Narain
中科院分区：
文献类型：
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作者：
Rajesh Sunasee;R. Narain
随着聚合技术的进步以及碳水化合物的选择性化学修饰，糖共聚物和糖纳米粒正在成为一类重要的材料，它们具有量身定制的性质或基于纳米技术的新平台，可用于许多应用。所谓的糖纳米技术领域开始显示出未来临床应用的一些希望。糖纳米粒由于其多功能性，可以为基于碳水化合物的疫苗的设计提供一个平台，并可能允许在未得到满足的疾病领域开发新的单剂疫苗。本文综述了基于碳水化合物的聚合物和纳米材料在生物分子识别过程和疫苗开发中的新作用。
With advances in polymerization techniques as well as selective chemical modification of carbohydrates, glycopolymers and glyco-nanoparticles are emerging as an important class of materials with tailored properties or novel nanotechnology-based platforms for a number of applications. The field of the so-called glyco-nanotechnology is starting to show some promises for future clinical applications. Glyco-nanoparticles, due to their versatile nature, could offer a platform for the design of carbohydrate-based vaccines and possibly allow the development of new single-dose vaccines in disease areas of unmet need. This paper surveys the emerging roles of carbohydrate-based polymeric and nanomaterials for biomolecular recognition processes and vaccine development.