Longitudinal electromyographic analysis of jaw-closing muscle activities during ingestive behaviors from pre-weaning to juvenile periods in rats
Longitudinal electromyographic analysis of jaw-closing muscle activities during ingestive behaviors from pre-weaning to juvenile periods in rats
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大鼠断奶前至幼年期摄食行为期间闭颌肌活动的纵向肌电图分析
DOI：
10.1016/j.physbeh.2023.114173
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发表时间：
2023
影响因子：
2.9
通讯作者：
Kato Takafumi
中科院分区：
文献类型：
--
作者：
Yamada Masaharu;Katagiri Ayano;Masuda Yuji;Toyoda Hiroki;Niwa Hitoshi;Kato Takafumi
本纵向研究调查了大鼠进食行为中颌部闭合肌肉活动的发育变化。在出生后第10天，将肌电（EMG）电极插入大鼠咬肌和颞肌。记录P14和P49之间的以下摄食行为的肌电图活动：P14的哺乳，包括乳头附着和有节奏的吮吸，P21和P49之间的意大利面咬，颗粒咀嚼和舔奶。对每个行为的咬肌和颞肌活动之间的爆发节律和肌肉协调（即相关性和时间滞后）进行评估。P14的乳头附着和有节奏吸吮的爆发节奏明显慢于P21的咬面食、咀嚼颗粒和舔奶。P14期哺乳与P21期咀嚼舔食的肌肉协调性存在差异。在P21和P49之间，观察到咬意大利面和咀嚼颗粒的爆发节律增加。咀嚼意大利面比咀嚼颗粒时爆发节律的增加率更高。咬面食的肌肉协调性在P21和P49之间没有显著变化，而咀嚼颗粒的肌肉协调性在P21和P24之间有显著变化，在P24之后趋于稳定。随着时间的推移，舔奶的爆发节奏没有显著变化，而两种肌肉活动之间的肌肉协调性在大约P35上从激动剂变为拮抗剂肌肉样活动。目前的研究结果表明，在断奶前出现了独特的节奏性闭颚肌活动模式，它们随着时间的推移而继续变化，并且在断奶后每种行为都表现出独特的发展动态。
This longitudinal study investigated developmental changes in jaw-closing muscle activities during ingestive behaviors in rats.On postnatal day (P) 10, electromyography (EMG) electrodes were inserted into the masseter and temporalis muscles of rat pups. EMG activities were recorded for the following ingestive behaviors between P14 and P49: for suckling, including nipple attachment and rhythmic sucking on P14 and for pasta biting, pellet chewing, and milk licking between P21 and P49. Burst rhythms and muscle coordination (i.e., the correlation and time lag) between masseter and temporalis activities were assessed for each behavior.The burst rhythms of nipple attachment and rhythmic sucking on P14 were significantly slower than those of pasta biting, pellet chewing, and milk licking on P21. Muscle coordination differed between suckling on P14 and mastication and licking on P21. Between P21 and P49, increases were observed in burst rhythms for pasta biting and pellet chewing. The rate of increases in burst rhythms was higher for pasta biting than for pellet chewing. Muscle coordination between the two muscle activities for pasta biting did not significantly change between P21 and P49, whereas that for pellet chewing significantly changed between P21 and P24 and stabilized after P24. Burst rhythms for milk licking did not significantly change over time, while muscle coordination between the two muscle activities changed from agonist to antagonist muscle-like activity on approximately P35.The present results demonstrate that distinct patterns of rhythmic jaw-closing muscle activities emerge before weaning, they continue to change over time, and they exhibit unique developmental dynamics for each behavior after weaning.