Transfer of ochratoxin A during lactation: exposure of suckling via the milk of rabbit does fed a naturally-contaminated feed
Transfer of ochratoxin A during lactation: exposure of suckling via the milk of rabbit does fed a naturally-contaminated feed
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DOI：
10.1080/026520300283522
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发表时间：
2000-02-01
期刊：
影响因子：
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通讯作者：
Ponchaut, S
中科院分区：
文献类型：
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作者：
Ferrufino-Guardia, EV;Tangni, EK;Ponchaut, S
研究了赭曲霉毒素A从哺乳期母兔的血液转移到乳汁中以及随后其幼崽暴露于真菌毒素的情况。在哺乳期19天的整个哺乳期内，饲喂天然污染饲料（10 - 20 g/kg体重/天）的哺乳期母兔显示出赭曲霉毒素A从血液有效转移到乳汁中。在整个哺乳期内，血浆和乳汁中的oxhratoxin A浓度没有显著变化，平均乳汁/血浆浓度比为0.015。然而，这些变量显著相关（p <0.05），摄入量和牛奶浓度也是如此。屠宰时，雌兔体内积累的赭曲霉毒素A浓度最高的是肾脏（1.2 g/kg），其次是肝脏（158 ng/kg）、乳腺（105 ng/kg）和肌肉（38 ng/kg）。在牛奶和血浆中的赭曲霉毒素A的浓度之间的线性关系被发现的哺乳动物，表明有效的毒素转移到哺乳动物。如果在人类中也是如此，那么母乳喂养的婴儿接触毒素（文献中已大量报道）应成为人类健康的一个主要问题。
The transfer of ochratoxin A from the blood to the milk of lactating rabbit does and subsequently the exposure of their sucklings to the mycotoxin were investigated An effective transfer of ochratoxin A from blood to milk was shown in lactating rabbit does fed a naturally-contaminated diet (10-20 g/kg of body weight/day) throughout a lactation period of 19 days. The oxhratoxin A concentrations in plasma and in milk did not significantly change throughout the lactation period,vith a mean milk/plasma concentration ratio of 0.015. These variables were however significantly correlated (p < 0.05), as were the ingested amounts and milk concentrations. At slaughter, the highest concentration of ochratoxin A accumulated in the body of the rabbit does were found in kidney (1.2 g/kg) followed by liver (158 ng/kg), mammary gland (105 ng/kg) and muscle (38 ng/kg). A linear relationship was found between the ochratoxin A concentrations in milk and in the plasma of the sucklings, indicating an effective transfer of the toxin to the sucklings. If the same is true in humans, the exposure of the breast-fed infant to the toxin, which has been largely reported in the literature, should be a majro matter of concern for human health.