Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers
Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers
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DOI：
10.1038/ejcn.2010.184
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发表时间：
2011-01-01
影响因子：
4.7
通讯作者：
Nesaretnam, K.
中科院分区：
文献类型：
--
作者：
Mahalingam, D.;Radhakrishnan, A. K.;Nesaretnam, K.
背景/目的：维生素E是一种必需的脂溶性维生素，已被证明对动物和人类免疫系统有良好的作用。本研究的目的是评估的影响生育三烯酚丰富的馏分（TRF）补充破伤风类毒素（TT）疫苗的挑战后，在健康的女性volunteers.Subjects/方法：在这个双盲，安慰剂对照的临床试验中，参与者被随机分配到接受安慰剂（对照组）或400毫克的TRF（研究组）补充剂，每天。在2个月的研究期间，要求志愿者参加三次临床会议（即第0、28和56天），并在随访期间从志愿者中采集血样。在第28天，所有的志愿者也接种TT疫苗（20 Lf）intramusculary.Results：从临床试验的结果表明，TRF补充显着增加TRF补充志愿者的血浆中的总维生素E水平与安慰剂组相比，表明总体依从性。补充TRF的志愿者，
Background/Objectives: Vitamin E is an essential fat-soluble vitamin that has been shown to induce favorable effects on animal and human immune systems. The objective of this study was to assess the effects of tocotrienol-rich fraction (TRF) supplementation on immune response following tetanus toxoid (TT) vaccine challenge in healthy female volunteers.Subjects/Methods: In this double-blinded, placebo-controlled clinical trial, participants were randomly assigned to receive either placebo (control group) or 400mg of TRF (study group) supplementation daily. Over the 2-month period of the study, volunteers were asked to attend three clinical sessions (that is, on days 0, 28 and 56) and blood samples were obtained from the volunteers during the follow-up. On day 28, all volunteers were also vaccinated with the TT vaccine (20 Lf) intramuscularly.Results: The results from the clinical trial showed that TRF supplementation significantly increased the total vitamin E level in the plasma of the TRF-supplemented volunteers compared with the placebo group, indicating overall compliance. Volunteers supplemented with TRF showed a significantly (P