Total synthesis of RK-397
Total synthesis of RK-397
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DOI：
10.1021/ja052226d
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发表时间：
2005-06-29
影响因子：
15
通讯作者：
Fujimori, S
中科院分区：
文献类型：
--
作者：
Denmark, SE;Fujimori, S
报道了多烯大环内酯RK-397的对映选择性合成方法。使用相同的八碳结构块两次构建多元醇链，可实现高度收敛的合成。该合成强调了使用手性双磷酰胺的立体选择性的乙烯基羟醛加成反应，以及用于制备关键片段的顺序的钯催化的交叉偶联反应。
An enantioselective synthesis of the polyene macrolide RK-397 is described. The use of the same eight-carbon building block twice for the construction of the polyol chain allowed for a highly convergent synthesis. The synthesis highlights stereoselective vinylogous aldol addition using a chiral bisphosphoramide as well as a sequential palladium-catalyzed cross-coupling reaction for the preparation of key fragments.