Viscoelastic Measurements of Vocal Folds Using the Linear Skin Rheometer
Viscoelastic Measurements of Vocal Folds Using the Linear Skin Rheometer
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DOI：
10.1016/j.jvoice.2007.01.002
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发表时间：
2009-03-01
期刊：
影响因子：
2.2
通讯作者：
Goodyer, Eric
中科院分区：
文献类型：
--
作者：
Dailey, Seth H.;Tateya, Ichiro;Goodyer, Eric
随着声带瘢痕干预措施的增加和数学建模的进步，声带柔韧性测量的准确性和精确性将变得至关重要。虽然间接柔韧性测量已被成功使用，但组织柔韧性的直接测量是必不可少的。使用平行板技术的间接测量具有局限性;它需要从周围框架中移除组织，不允许部位特异性，并且不提供动物或人类体内使用的未来。我们测试了线性技能流变仪（LSR）在评价声带柔韧性方面的作用。我们测量了声带的特定部位流变学，从而在人、狗和大鼠尸体喉中在刚度改变的条件下创建“柔韧性图”;犬声带具有沟，大鼠声带继发于受控活检而僵硬，而人声带注射三氯乙酸。进行组织学检查以确认犬齿沟的位置和类型。我们发现LSR可靠地检测到所有物种的声带硬度，并创建了与以前的数据和临床观察一致的“柔韧性图”。LSR应证明在评价声带柔韧性的离体和最终在体内。体内应用。
As the number of interventions for vocal fold scar grows and with the advancement of mathematical modeling, greater accuracy and precision in the measurement of vocal fold pliability will become essential. Although indirect pliability measures have been used successfully, direct measurement of tissue pliability is essential. Indirect measurement with parallel plate technology has limitations; it requires the tissue to be removed from the surrounding framework, allows no site specificity, and offers no future for in vivo use in animals or humans. We tested the linear skill rheometer (LSR) in the evaluation of vocal fold pliability. We measured site-specific rheology of vocal folds thereby creating "pliability maps" in human, dog, and rat cadaveric larynges under conditions of altered stiffness; the canine vocal folds possessed sulci, the rat vocal fold was stiff secondary to controlled biopsy, and the human vocal fold was injected with trichloroacetic acid. Histology was performed to confirm the site and type of canine sulci. We found that the LSR reliably detected stiffness in the vocal folds of all species and created "pliability maps" consistent with previous data and clinical observations. The LSR should prove useful in the evaluation of vocal fold pliability for ex vivo and ultimately for in. vivo applications.