Attenuation of amphotericin-B nephrotoxicity in the candidiasis rat model.
Attenuation of amphotericin-B nephrotoxicity in the candidiasis rat model.
复制标题
念珠菌病大鼠模型中两性霉素 B 肾毒性的减弱。
DOI：
10.1159/000186533
复制
发表时间：
1991
期刊：
影响因子：
2.5
通讯作者：
Lopez-Berestein,G
中科院分区：
文献类型：
--
作者：
Luke,DR;Wasan,KM;Verani,RR;Brunner,LJ;Berens,KL;Vadiei,K;Lopez-Berestein,G
Dose-limiting nephrotoxicity has hampered the clinical usefulness of amphotericin-B (AmpB). Recently, vascular decongestants, such as pentoxifylline, have shown benefit in reducing drug-associated renal damage of AmpB in rats. The present study investigated a dose-dependent protection of a structurally similar methylxanthine, HWA-448, in the candidiasis rat model given a single dose of AmpB. Forty-eight hours after inoculation withCandida albicans,each rat was treated with 0.8 mg/kg of AmpB or sterile water; animals were further randomized to receive 0.5, 1, 5, or 10 mg/kg i.v. of H WA-448 or saline given every 12 h for 3 doses. Kidney fungal counts, morphology, and renal function were compared between treatment groups upon completion of the study. Rats administered AmpB with HWA-448 had markedly improved renal function compared with those given AmpB alone; these effects were independent of the administered dose of HWA-448. The antifungal effect of AmpB was not impaired with concomitant HWA-448. Marked accumulation of granulomas and organisms was found in all rat groups. In summary, coadministration of low doses of HWA-448 attenuated the dose-limiting nephrotoxicity without impairing the antifungal effect of AmpB.
