Preparation and characterization of cellulose-based foams via microwave curing
Preparation and characterization of cellulose-based foams via microwave curing
复制标题
DOI：
10.1098/rsfs.2013.0053
复制
发表时间：
2014-02-06
期刊：
影响因子：
4.4
通讯作者：
Ambrosio, Luigi
中科院分区：
文献类型：
--
作者：
Demitri, Christian;Giuri, Antonella;Ambrosio, Luigi
在这项工作中，羧甲基纤维素钠盐（CMCNa）和聚乙二醇二丙烯酸酯（PEGDA 700）的混合物用于制备微孔结构，通过使用两种不同的程序的组合。首先，使用Pluronic作为发泡剂诱导物理发泡，然后进行化学稳定。该第二步通过偶氮双（2-甲基丙脒）二盐酸盐作为热引发剂（TI）进行。通过使用微波发生器均匀加热样品来活化该反应。最后，研究了不同CMCNa和PEGDA 700比例对泡沫最终性能的影响。评价各样品的粘度、吸水能力、弹性模量和多孔结构。此外，还进行了初步生物学表征，旨在证明所得材料的生物相容性。在混合物中包括20%PEGDA 700的泡沫在热聚合之前表现出较高的粘度和稳定性。此外，该样品的吸水能力、机械阻力和更均匀的微孔结构也得到了提高。特别是，含有3% CMCNa的泡沫显示出具有不同尺寸开孔的分层结构。这种形态增加了泡沫的性能。全套样品表现出良好的生物相容性，细胞增殖率超过7天。
In this work, a mixture of a sodium salt of carboxymethylcellulose (CMCNa) and polyethylene glycol diacrylate (PEGDA700) was used for the preparation of a microporous structure by using the combination of two different procedures. First, physical foaming was induced using Pluronic as a blowing agent, followed by a chemical stabilization. This second step was carried out by means of an azobis(2-methylpropionamidine) dihydrochloride as the thermoinitiator (TI). This reaction was activated by heating the sample homogeneously using a microwave generator. Finally, the influence of different CMCNa and PEGDA700 ratios on the final properties of the foams was investigated. The viscosity, water absorption capacity, elastic modulus and porous structure were evaluated for each sample. In addition, preliminary biological characterization was carried out with the aim to prove the biocompatibility of the resulting material. The foam, including 20% of PEGDA700 in the mixture, demonstrated higher viscosity and stability before thermo-polymerization. In addition, increased water absorption capacity, mechanical resistance and a more uniformmicroporous structure were obtained for this sample. In particular, foam with 3% of CMCNa shows a hierarchical structure with open pores of different sizes. This morphology increased the properties of the foams. The full set of samples demonstrated an excellent biocompatibility profile with a good cell proliferation rate of more than 7 days.