Limbic circuitry of the midline thalamus.
Limbic circuitry of the midline thalamus.
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DOI：
10.1016/j.neubiorev.2015.01.014
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发表时间：
2015-07
影响因子：
8.2
通讯作者：
Hoover WB
中科院分区：
文献类型：
--
作者：
Vertes RP;Linley SB;Hoover WB
丘脑分为三个主要的群体：感觉运动核（或主/中继核），边缘核和核桥接这两个领域。丘脑的边缘核（或“边缘丘脑”）由前核、中线核、内侧背核内侧部（MDm）和板内复合体的中央内侧核（CM）组成。中线核包括背侧的室旁核（PV）和带旁核（PT），腹侧的连合核（RE）和菱形核（RH）。“边缘”丘脑核主要与边缘相关结构连接，并在边缘相关功能中发挥直接作用。关于中线核，RE/RH主要针对边缘皮质结构，特别是海马和内侧前额叶皮质。因此，RE/RH参与涉及HF和mPFC相互作用的功能。相比之下，PV/PT主要投射到边缘皮层下结构，特别是杏仁核和杏仁核，因此与情感行为如应激/焦虑、进食行为和药物寻求活动密切相关。MDm和CM的解剖学/功能特征与中线核的解剖学/功能特征非常相似，因此沿着丘脑中线/副中线背腹延伸的核的集合构成了“边缘丘脑”的核心。
The thalamus was subdivided into three major groups: sensorimotor nuclei (or principal/relay nuclei), limbic nuclei and nuclei bridging these two domains. Limbic nuclei of thalamus (or ‘limbic thalamus’) consist of the anterior nuclei, midline nuclei, medial division of the mediodorsal nucleus (MDm) and central medial nucleus (CM) of the intralaminar complex. The midline nuclei include the paraventricular (PV) and paratenial (PT) nuclei, dorsally, and the reuniens (RE) and rhomboid (RH) nuclei, ventrally. The ‘limbic’ thalamic nuclei predominantly connect with limbic-related structures and serve a direct role in limbic–associated functions. Regarding the midline nuclei, RE/RH mainly target limbic cortical structures, particularly the hippocampus and the medial prefrontal cortex. Accordingly, RE/RH participate in functions involving interactions of the HF and mPFC. By contrast, PV/PT mainly project to limbic subcortical structures, particularly the amygdala and nucleus accumbens, and hence are critically involved in affective behaviors such as stress/anxiety, feeding behavior, and drug seeking activities. The anatomical/functional characteristics of MDm and CM are very similar to those of the midline nuclei and hence the collection of nuclei extending dorsoventrally along the midline/paramidline of the thalamus constitute the core of the ‘limbic thalamus’.