Regenerative medicine in China: main progress in different fields.
Regenerative medicine in China: main progress in different fields.
复制标题
中国再生医学：不同领域的主要进展
DOI：
10.1186/s40779-016-0096-z
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发表时间：
2016
影响因子：
21.1
通讯作者：
Fu XB
中科院分区：
文献类型：
--
作者：
Cheng B;Lu SL;Fu XB
再生医学（RM）是一个新兴的交叉学科研究领域，中国在干细胞、组织工程、活性分子和基因治疗等方面的研究进展迅速，取得了令世界瞩目的众多研究成果。重要方向是诱导多能干细胞和胚胎干细胞的诱导分化以及成体干细胞分化潜力及其在创伤、烧伤、衰老疾病和神经再生中的应用。产品ActivSkin和骨修复支架已获批并应用于临床，类似产品正在研究中。大约10种用于修复和再生的工程生长因子药物已获得批准并用于临床。基因治疗、治疗性克隆和异种移植是正在研究的一些策略。然而，中国需要制定适合RM健康发展的标准、法规和管理规范。需要加强的方面包括健全管理制度、法律、技术规范和指南；保护干细胞资源；重视培训和保留有才华的干细胞研究人员；合理配置资源，多元化投入，重点突破。最后，广泛而深入的国际合作是必要的。
Regenerative medicine (RM) is an emerging interdisciplinary field of research and China has developed the research quickly and impressed the world with numerous research findings in stem cells, tissue engineering, active molecules and gene therapy. Important directions are induced differentiation of induced pluripotent stem and embryo stem cells as well as somatic stem cell differentiation potential and their application in trauma, burns, diseases of aging and nerve regeneration. The products ActivSkin and bone repair scaffolds have been approved and are applied in the clinic, and similar products are being studied. About 10 engineered growth-factor drugs for repair and regeneration have been approved and are used in the clinic. Gene therapy, therapeutic cloning and xenotransplantation are some of the strategies being studied. However, China needs to develop standards, regulations and management practices suitable for the healthy development of RM. Aspects that should be strengthened include sound administrative systems, laws, and technical specifications and guidelines; conservation of stem cell resources; emphasis on training and retention of talented stem cell researchers; and reasonable allocation of resources, diversification of investment and breakthroughs in key areas. Finally, broad and deep international cooperation is necessary.