Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide.
Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide.
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发表时间：
2004
影响因子：
6.7
通讯作者：
Hae-Young Park;Sung-Hwan Park;Hae-Kyung Yoon;M. Han;Dong-Hyun Kim
中科院分区：
文献类型：
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作者：
Hae-Young Park;Sung-Hwan Park;Hae-Kyung Yoon;M. Han;Dong-Hyun Kim
甘草甜素（18 β-甘草次酸-3-O-β-D-吡喃葡萄糖醛酸基-（1 -> 2）-β-D-葡萄糖醛酸苷，GL）被链球菌LJ-22转化为18 β-甘草次酸-3-O-β-D-葡萄糖醛酸苷（GAMG）。采用RBL细胞分析系统和接触性超敏反应模型小鼠测定GL和GAMG的抗过敏活性。GAMG具有抗过敏活性，IC 50值为0.28 mM。GAMG比GL甜，18 β-大黄次酸是GAMG在人体肠道细菌中的代谢产物，也可抑制被动皮肤过敏反应和皮肤接触性炎症。因此，GAMG可作为一种新型的甜味食品添加剂和抗过敏剂。
Glycyrrhizin (18beta-glycyrrhetinic acid-3-O-beta-D-glucuronopyranosyl-(1 --> 2)-beta-D-glucuronide, GL) was transformed to 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide (GAMG) by Streptococcus LJ-22. The antiallergic activities of GL and GAMG was measured using a RBL cell assay system and contact hypersensitivity model mice. GAMG exhibited anti-allergic activity with IC50 values of 0.28 mM. GAMG, which is sweeter than GL, and 18beta-glycyrrhetinic acid, which is a GAMG metabolite by human intestinal bacteria, also inhibited the passive cutaneous anaphylaxis and skin contact inflammation. In conclusion, GAMG may be useful as a new sweet food additive and an anti-allergic agent.