Distinct neural codes in primate hippocampus and lateral prefrontal cortex during associative learning in virtual environments
Distinct neural codes in primate hippocampus and lateral prefrontal cortex during associative learning in virtual environments
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DOI：
10.1016/j.neuron.2022.04.016
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发表时间：
2022-07-06
期刊：
影响因子：
16.2
通讯作者：
Martinez-Trujillo，Julio C.
中科院分区：
文献类型：
--
作者：
Corrigan，Benjamin W.;Gulli，Roberto A.;Martinez-Trujillo，Julio C.
海马（HPC）和外侧前额叶皮层（LPFC）是灵长类动物大脑中被认为对认知至关重要的两个皮层区域。在这里，我们假设，代码介导的HPC和LPFC微电路的神经元通信已经独特地演变为在不同的时空尺度上的可塑性和记忆功能。我们使用了一个虚拟现实任务，在这个任务中，动物根据学习的上下文颜色规则选择迷宫臂中的两个目标之一。我们的研究结果表明，在联想学习过程中，HPC主细胞集中在突发尖峰，使时间总和和快速突触可塑性在小群体的神经元，并最终促进快速编码的联想记忆。另一方面，第II/III层LPFC锥体细胞随着时间的推移发射更稀疏分布的尖峰。后者将促进短期记忆中加载的信号在神经元群体中的传播，而不一定触发快速突触可塑性。
The hippocampus (HPC) and the lateral prefrontal cortex (LPFC) are two cortical areas of the primate brain deemed essential to cognition. Here, we hypothesized that the codes mediating neuronal communication in the HPC and LPFC microcircuits have distinctively evolved to serve plasticity and memory function at different spatiotemporal scales. We used a virtual reality task in which animals selected one of the two targets in the arms of the maze, according to a learned context-color rule. Our results show that during associative learning, HPC principal cells concentrate spikes in bursts, enabling temporal summation and fast synaptic plasticity in small populations of neurons and ultimately facilitating rapid encoding of associative memories. On the other hand, layer II/III LPFC pyramidal cells fire spikes more sparsely distributed over time. The latter would facilitate broadcasting of signals loaded in short-term memory across neuronal populations without necessarily triggering fast synaptic plasticity.