Improved Fertility Preservation Care for Male Patients With Cancer After Establishment of Formalized Oncofertility Program
Improved Fertility Preservation Care for Male Patients With Cancer After Establishment of Formalized Oncofertility Program
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DOI：
10.1016/j.juro.2011.10.154
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发表时间：
2012-03-01
影响因子：
6.6
通讯作者：
Brannigant, Robert E.
中科院分区：
文献类型：
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作者：
Sheth, Kunj R.;Sharma, Vidit;Brannigant, Robert E.
目的：男性癌症患者的生育年龄存活率稳步上升，但癌症治疗和癌症本身可能带来不孕的风险。自2006年以来，我们在我们的机构使用了正式的生育保留计划和加速生育护理。我们评估了这一计划的影响，通过比较精子冷冻保存的频率和病人的特点，在其implementation.Materials和方法：男性18至55岁诊断为癌症在我们的机构从2002年至2010年被纳入我们的研究。我们回顾性地回顾了患者的病历，以确定那些谁提供，随后使用生育保存服务之前和之后的程序formalization.Results：从2002年至2010年在我们的机构4,818名男性18至55岁被诊断为癌症，其中411人提供生育保存咨询和249人接受精子冷冻保存。自该计划实施以来，每年接受生育力保存咨询和精子冷冻保存的男性人数分别增加了2.4倍和2.7倍，而被诊断患有癌症的总人数保持相当稳定。在将患者分为更传统的生育年龄范围（18至40岁）后，该组中所有癌症患者中有23.4%在正式化前接受了咨询，而正式化后为43.3%（p
Purpose: Survival to reproductive age among men with cancer has steadily increased and yet cancer therapy and cancer itself may carry the risk of infertility. Since 2006, we have used a formalized fertility preservation program with expedited fertility care at our institution. We assessed the impact of this program by comparing the frequency of sperm cryopreservation and patient characteristics before and after its implementation.Materials and Methods: Men 18 to 55 years old diagnosed with cancer at our institution from 2002 to 2010 were included in our study. We retrospectively reviewed patient charts to identify those who were offered and subsequently used fertility preservation services before and after program formalization.Results: From 2002 to 2010 at our institution 4,818 men 18 to 55 years old were diagnosed with cancer, of whom 411 were offered fertility preservation consultation and 249 underwent sperm cryopreservation. Since program implementation, the annual number of men receiving fertility preservation consultation and undergoing sperm cryopreservation increased by 2.4 and 2.7-fold, respectively, while the total number diagnosed with cancer remained fairly constant. Upon substratifying patients into the more conventional reproductive age range of 18 to 40 years 23.4% of all men with cancer in this group were offered consultation before formalization vs 43.3% after formalization (p