Unstimulated and Amphetamine‐Stimulated Release of Endogenous Noradrenaline and Dopamine from Rat Brain In Vivo
Unstimulated and Amphetamine‐Stimulated Release of Endogenous Noradrenaline and Dopamine from Rat Brain In Vivo
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大鼠脑体内未刺激和安非他明刺激的内源性去甲肾上腺素和多巴胺的释放
DOI：
10.1111/j.1471-4159.1982.tb05354.x
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发表时间：
1982
影响因子：
4.7
通讯作者：
A. Boulton
中科院分区：
文献类型：
--
作者：
S. Philips;A. Robson;A. Boulton
摘要：测定了大鼠下丘脑内源性去甲肾上腺素和尾状核内源性多巴胺的体内释放率。人工脑脊液灌注从推拉套管插入大脑的特定区域收集，通过灵敏的放射酶程序检测胺。人工脑脊液中去甲肾上腺素和多巴胺的释放率分别为38±6和46±6 pg/h(225±36和301±39 fmol/h)；当0.5 mM安非他明加入脑脊液时，去甲肾上腺素和多巴胺的释放率分别增加到176±50和1183±453 pg/h（1041±296和7732±2961 fmol/h）。
Abstract: The in vivo release rates of endogenous noradrenaline from the hypothalamus and dopamine from the caudate nucleus of the rat have been determined. Artificial CSF perfusates collected from a push‐pull cannula inserted into specific areas of the brain were assayed for the amines by a sensitive radioenzymatic procedure. The release rates of noradrenaline and dopamine into artificial CSF perfusates were 38 ± 6 and 46 ± 6 pg/h (225 ± 36 and 301 ± 39 fmol/h), respectively; when 0.5 mM amphetamine was added to the CSF, the release rates of noradrenaline and dopamine increased to 176 ± 50 and 1183 ± 453 pg/h (1041 ± 296 and 7732 ± 2961 fmol/h), respectively.