Natural Anthraquinone Derivatives from a Marine Mangrove Plant-Derived Endophytic Fungus Eurotium rubrum: Structural Elucidation and DPPH Radical Scavenging Activity
Natural Anthraquinone Derivatives from a Marine Mangrove Plant-Derived Endophytic Fungus Eurotium rubrum: Structural Elucidation and DPPH Radical Scavenging Activity
复制标题
海洋红树林植物源性内生真菌红色散囊的天然蒽醌衍生物：结构解析和 DPPH 自由基清除活性
DOI：
10.4014/jmb.0805.342
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发表时间：
2009-07-01
影响因子：
2.8
通讯作者：
Wang, Bin-Gui
中科院分区：
文献类型：
--
作者：
Li, Dong-Li;Li, Xiao-Ming;Wang, Bin-Gui
人们对从自然资源中分离出强效自由基清除化合物来治疗涉及氧化应激的疾病非常感兴趣。本文从褐皮菌中分离鉴定了4个新的真菌代谢产物，包括1个新的双氢蒽醌衍生物（1,eurorubrin）、2个新的仲蒽醌衍生物[3,2 - o-甲基-9-去羟基尿苷酮和4,2 - o-甲基- o- （α -d -核呋喃基）-9-去羟基尿苷酮]和1个新的蒽醌苷[6,3- o- （α -d -核呋喃基）问题素]。从海洋红树林植物木槿茎的内部组织中分离出来的一种内生真菌菌株。此外，还分离鉴定了3种已知化合物asperflavin(2)、2- o -methyl leurotinone(5)和questin(7)。在光谱分析的基础上对它们的结构进行了鉴定。所有分离得到的化合物均具有清除1,1-二苯基-2-苦味酰肼（DPPH）自由基的活性。
There is considerable interest in the isolation of potent radical scavenging compounds from natural resources to treat diseases involving oxidative stress. In this report, four new fungal metabolites including one new bisdihydroanthracenone derivative (1, eurorubrin), two new seco-anthraquinone derivatives [3, 2-O-methyl-9-dehydroxyeurotinone and 4, 2-O-methyl4-O-(alpha-D-ribofuranosyl)-9-dehydroxyeurotinone], and one new anthraquinone glycoside [6,3-O-(alpha-D-ribofuranosyl)questin], were isolated and identified from Eurotium rubrum, an endophytic fungal strain that was isolated from the inner tissue of the stem of the marine mangrove plant Hibiscus tiliaceus. In addition, three known compounds including asperflavin (2), 2-O-methyleurotinone (5), and questin (7) were also isolated and identified. Their structures were elucidated on the basis of spectroscopic analysis. All of the isolated compounds were evaluated for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity.