LIPOFUSION ACCUMULATION RESULTING FROM SENESCENCE AND VITAMIN-E-DEFICIENCY - SPECTRAL PROPERTIES AND TISSUE DISTRIBUTION
LIPOFUSION ACCUMULATION RESULTING FROM SENESCENCE AND VITAMIN-E-DEFICIENCY - SPECTRAL PROPERTIES AND TISSUE DISTRIBUTION
复制标题
DOI：
10.1016/0047-6374(84)90137-4
复制
发表时间：
1984-01-01
影响因子：
5.3
通讯作者：
BIERI, JG
中科院分区：
文献类型：
--
作者：
KATZ, ML;ROBISON, WG;BIERI, JG
本文研究了白化病大鼠在正常衰老和维生素E缺乏时自发荧光色素的校正荧光发射光谱和组织分布。在视网膜色素上皮中，与年龄相关的色素（脂褐素）和与维生素E缺乏相关的色素具有基本相同的发射光谱。峰值发射出现在590-650 nm。幼鼠断奶后17周一直保持在维生素E缺乏的饮食显示出显着的积累的自发荧光色素在子宫，十二指肠和视网膜色素上皮，但不是在脊髓或下橄榄核的大脑。老年动物（96周）喂养的商业饮食与足够的维生素E积累脂褐素在视网膜色素上皮，脊髓灰质和下橄榄核，但不是在十二指肠或子宫。虽然与衰老和维生素E缺乏有关的自发荧光色素具有相似的性质，但它们的组织分布却截然不同。
Corrected fluorescence emission spectra and tissue distributions of the autofluorescent pigments which accumulate during normal aging and as a consequence of vitamin E deficiency were studied in albino rats. In the retinal pigment epithelium, the age-related pigment (lipofuscin) and the pigment related to vitamin E deficiency had essentially identical emission spectra. Peak emission occurred from 590-650 nm. Young animals which has been kept on a vitamin E deficient diet for 17 wk after weaning showed significant accumulations of autofluorescent pigment in uterus, duodenum and retinal pigment epithelium, but not in the spinal cord or inferior olivary nucleus of the brain. Old animals (96 wk) fed a commercial diet with adequate vitamin E had accumulated lipofuscin in the retinal pigment epithelium, spinal cord gray matter and inferior olivary nucleus, but not in the duodenum or uterus. While the autofluorescent pigments related to aging and vitamin E dficiency have similar properties, their tissue distributions are quite different.